Medizinische Universität Graz - Research portal
Selected Publication:
Gelband, CH; Silberberg, SD; Groschner, K; van Breemen, C.
ATP inhibits smooth muscle Ca2(+)-activated K+ channels.
Proc Biol Sci. 1990; 242(1303):23-28
Doi: 10.1098/rspb.1990.0098
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-authors Med Uni Graz
- Groschner Klaus
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- There has been much recent interest in the roles played by smooth-muscle K+ channels in protecting cells against ischemic and anoxic insults and in therapeutic vaso- and bronchodilation (Buckingham 1990; Longmore & Weston 1990). A K+ channel, which is uniquely sensitive to cytoplasmic ATP (KATP), has been identified as a likely candidate for mediating these important functions (Standen et al. 1989). We now show, by using electrophysiological techniques in three different types of smooth muscle, that a large-conductance voltage and Ca2(+)-sensitive channel, otherwise indistinguishable from the the large-conductance Ca2(+)-activated K+ channel (BK channel), is also sensitive to cytoplasmic ATP and cromakalim. ATP, in a dose-dependent manner, decreased the probability of channel opening (Po) of rabbit aortic, rabbit tracheal and pig coronary artery BK channels with a Ki of 0.2-0.6 mM. Cromakalim, 10 microM, partially reversed the ATP induced inhibition and increased Po. Our observations raise the possibility that the ubiquitous BK channel may play a role during pathophysiological events.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenosine Triphosphate - pharmacology
- Animals -
- Calcium - pharmacology
- Cells, Cultured -
- Lipid Bilayers -
- Muscle, Smooth - drug effects Muscle, Smooth - metabolism
- Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism
- Potassium Channels - drug effects Potassium Channels - metabolism
- Rabbits -
- Swine -