Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Beinhardt, S; Aberle, JH; Strasser, M; Dulic-Lakovic, E; Maieron, A; Kreil, A; Rutter, K; Staettermayer, AF; Datz, C; Scherzer, TM; Strassl, R; Bischof, M; Stauber, R; Bodlaj, G; Laferl, H; Holzmann, H; Steindl-Munda, P; Ferenci, P; Hofer, H.
Serum level of IP-10 increases predictive value of IL28B polymorphisms for spontaneous clearance of acute HCV infection.
Gastroenterology. 2012; 142(1):78-85
Doi: 10.1053/j.gastro.2011.09.039
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Stauber Rudolf
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND & AIMS: Single nucleotide polymorphisms (SNPs) in IL28B and serum levels of interferon gamma inducible protein 10 (IP-10) predict outcomes of antiviral therapy in patients with chronic hepatitis C. We associated IL28B SNPs rs12979860 and rs8099917, along with serum levels of IP-10, with outcomes of patients with acute hepatitis C (AHC). METHODS: We studied 120 patients with AHC (64 male; 37 +/- 16 years old) and 96 healthy individuals (controls). The IL28B SNPs rs12979860 and rs8099917 were detected using real-time polymerase chain reaction; serum concentrations of IP-10 were measured by enzyme-linked immunosorbent assays of 62 patients with AHC. RESULTS: Hepatitis C virus was cleared spontaneously from 59 patients (49.2%). The IL28B rs12979860 C/C genotype was more frequent among patients with AHC than controls (62.5% vs 39.6%; P < .001) and among patients with spontaneous clearance than those without (74.6% vs 51.7%; P = .02) (positive predictive value, 60.3%). Patients with IL28B rs12979860 C/C more frequently developed jaundice (53.2% vs 27.6%; P = .022) than carriers of the T allele. The median level of IP-10 was lower among patients with AHC and spontaneous clearance (764 [113-2470] pg/mL) than those without spontaneous clearance (1481 [141-4412] pg/mL; P = .006). Based on receiver operating characteristic analysis, 540 pg/mL IP-10 was set as the cutoff for patients most likely to have spontaneous clearance (positive predictive value, 71.4%; negative predictive value, 65.9%). Including data on IP-10 levels increased the ability of the IL28B rs12979860 C/C to identify patients most likely to have spontaneous clearance (83% of those who had an IP-10 level <540 pg/mL and 32% who had an IP-10 level >540 pg/mL) (P < .01). CONCLUSIONS: The combination of serum level of IP-10 and SNPs in IL28B can identify patients with AHC who are most likely to undergo spontaneous clearance and those in need of early antiviral therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Adult -
- Aged -
- Aged, 80 and over -
- Aged, 80 and over -
- Biological Markers - blood
- Case-Control Studies -
- Chemokine CXCL10 - blood
- Enzyme-Linked Immunosorbent Assay -
- Female -
- Gene Frequency -
- Genotype -
- Hepacivirus - genetics
- Hepatitis C - blood
- Humans -
- Interleukins - genetics
- Logistic Models -
- Male -
- Middle Aged -
- Phenotype -
- Polymorphism, Single Nucleotide -
- Predictive Value of Tests -
- Prognosis -
- RNA, Viral - blood
- ROC Curve -
- Real-Time Polymerase Chain Reaction -
- Remission, Spontaneous -
- Viral Load -
- Young Adult -
- Find related publications in this database (Keywords)
- ROC Analysis
- Prognostic Factors
- Clinical Trial
- CXC-L10