Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Holzer, P; Peskar, BM; Peskar, BA; Amann, R.
Release of calcitonin gene-related peptide induced by capsaicin in the vascularly perfused rat stomach.
Neurosci Lett. 1990; 108(1-2):195-200
Doi: 10.1016/0304-3940(90)90730-W
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- Führende Autor*innen der Med Uni Graz
- Holzer Peter
- Co-Autor*innen der Med Uni Graz
- Peskar Bernhard
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- Abstract:
- It has been suggested that capsaicin-induced gastric mucosal protection results from the local release of vasodilator peptides such as calcitonin gene-related peptide (CGRP) from afferent nerve endings within the stomach, since CGRP is able to reduce gastric lesion formation. This concept is supported by the present finding that capsaicin (10(-5) M), administered to the vascularly perfused stomach of the rat, produces a more than 30-fold rise of the CGRP content of the venous effluent. High-pressure liquid chromatography revealed only one peak of immunoreactivity coeluting with synthetic CGRP.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcitonin Gene-Related Peptide - metabolism
- Capsaicin - pharmacology
- Male - pharmacology
- Perfusion - pharmacology
- Rats - pharmacology
- Rats, Inbred Strains - pharmacology
- Stomach - drug effects