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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Fröhlich, E; Roblegg, E.
Models for oral uptake of nanoparticles in consumer products.
Toxicology. 2012; 291(1-3):10-17
Doi: 10.1016/j.tox.2011.11.004
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- Leading authors Med Uni Graz
- Fröhlich Eleonore
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- Abstract:
- Presently, many consumer products contain nano-sized materials (NMs) to improve material properties, product quality and ease of use. NMs in food additives and in cosmetic articles (e.g., tooth paste) may be taken up by the oral route. As adverse effects of environmental nanoparticles, like ultrafine particles, have been reported, consumers worry about potential risks when using products containing NMs. The review focuses on metal and metal oxide NMs as common additives in tooth paste and in food industry and exposure by the oral route. Testing of NMs for oral exposure is very complex because differences in the diet, in mucus secretion and composition, in pH, in gastrointestinal transit time and in gastrointestinal flora influence NM uptake. Acellular (mucus, saliva) and epithelial layer of the orogastrointestinal barrier are described. Expected exposure doses, interaction of the NMs with mucus and permeation through the epithelium as well as in vivo data are mentioned. The role of in vitro models for the study of parameters relevant for ingested NMs is discussed.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. - Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Consumer Product Safety -
- Cosmetics -
- Environmental Exposure -
- Food -
- Gastrointestinal Tract - metabolism
- Humans -
- Intestinal Mucosa - metabolism
- Metals - administration and dosage
- Models, Biological -
- Mucous Membrane - metabolism
- Nanoparticles -
- Permeability -
- Toothpastes - analysis
- Find related publications in this database (Keywords)
- Nanomaterials
- Epithelial barriers
- Consumer products
- Titanium dioxide
- Silicon oxide
- Silver