Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mrak, K; Jagoditsch, M; Leibl, S; Klingler, A; Tschmelitsch, J.
Influence of pT3 subgroups on outcome of R0-resected colorectal tumors.
SOUTH MED J. 2011; 104(11): 722-730.
Doi: 10.1097/SMJ.0b013e3182321271
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Mrak Karl
- Co-Autor*innen der Med Uni Graz
- Leibl Sebastian
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- Abstract:
- Objective: Evaluate whether depth of infiltration within T3 colorectal tumors influences long-term oncologic outcome. Patients and Methods: Patients with stage pT3 colon and rectal tumors were divided into four subgroups according to the depth of infiltration. The influence on overall and disease-free survival was tested for each subgroup and compared in univariate and multivariate analyses. Results: A total of 368 patients were evaluated, with a median follow-up time of 92.5 months. In 181 patients with colon cancer 5- and 10-year overall survival rates were 82.7% and 65.0%, respectively, and 5- and 10-year disease-free survival rates were 80.9% and 64.4%, respectively. For 187 patients, rectal cancer 5- and 10-year overall survival rates were 69.0% and 50.5%, respectively, and disease-free survival rates were 61.3% and 47.5%, respectively. In either colon or rectal cancer, different pT3 categories showed neither a statistically significant influence on survival nor the occurrence of local or distant recurrence in univariate and multivariate analyses; however, higher pT3 subgroups had a significant influence on lymph node involvement and vessel invasion in patients with rectal cancer. Conclusions: Subdivision of pT3 tumors in colon cancer based on depth of infiltration does not provide additional information about prognosis. In rectal cancer, T3 substages were associated with lymph node involvement; however, we could not demonstrate an impact on recurrence or survival.
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- Find related publications in this database (Keywords)
- colorectal cancer
- infiltration depth
- pT3 substaging
- recurrence rates
- survival rates