Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pepke-Zaba, J; Delcroix, M; Lang, I; Mayer, E; Jansa, P; Ambroz, D; Treacy, C; D'Armini, AM; Morsolini, M; Snijder, R; Bresser, P; Torbicki, A; Kristensen, B; Lewczuk, J; Simkova, I; Barberà, JA; de Perrot, M; Hoeper, MM; Gaine, S; Speich, R; Gomez-Sanchez, MA; Kovacs, G; Hamid, AM; Jaïs, X; Simonneau, G.
Chronic thromboembolic pulmonary hypertension (CTEPH): results from an international prospective registry.
CIRCULATION. 2011; 124(18): 1973-1981.
Doi: 10.1161/CIRCULATIONAHA.110.015008
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- Co-Autor*innen der Med Uni Graz
- Kovacs Gabor
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- Abstract:
- Background-Chronic thromboembolic pulmonary hypertension (CTEPH) is often a sequel of venous thromboembolism with fatal natural history; however, many cases can be cured by pulmonary endarterectomy. The clinical characteristics and current management of patients enrolled in an international CTEPH registry was investigated. Methods and Results-The international registry included 679 newly diagnosed (<= 6 months) consecutive patients with CTEPH, from February 2007 until January 2009. Diagnosis was confirmed by right heart catheterization, ventilation-perfusion lung scintigraphy, computerized tomography, and/or pulmonary angiography. At diagnosis, a median of 14.1 months had passed since first symptoms; 427 patients (62.9%) were considered operable, 247 (36.4%) nonoperable, and 5 (0.7%) had no operability data; 386 patients (56.8%, ranging from 12.0%-60.9% across countries) underwent surgery. Operable patients did not differ from nonoperable patients relative to symptoms, New York Heart Association class, and hemodynamics. A history of acute pulmonary embolism was reported for 74.8% of patients (77.5% operable, 70.0% nonoperable). Associated conditions included thrombophilic disorder in 31.9% (37.1% operable, 23.5% nonoperable) and splenectomy in 3.4% of patients (1.9% operable, 5.7% nonoperable). At the time of CTEPH diagnosis, 37.7% of patients initiated at least 1 pulmonary arterial hypertension-targeted therapy (28.3% operable, 53.8% nonoperable). Pulmonary endarterectomy was performed with a 4.7% documented mortality rate. Conclusions-Despite similarities in clinical presentation, operable and nonoperable CTEPH patients may have distinct associated medical conditions. Operability rates vary considerably across countries, and a substantial number of patients (operable and nonoperable) receive off-label pulmonary arterial hypertension-targeted treatments. (Circulation. 2011; 124: 1973-1981.)
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Chronic Disease -
- Endarterectomy - mortality
- Female -
- Humans -
- Hypertension, Pulmonary - drug therapy
- Incidence -
- Internationality -
- Male -
- Middle Aged -
- Phosphodiesterase 5 Inhibitors - therapeutic use
- Prospective Studies -
- Prostaglandins I - therapeutic use
- Receptors, Endothelin - antagonists & inhibitors
- Recurrence -
- Registries -
- Risk Factors -
- Vena Cava Filters - statistics & numerical data
- Venous Thromboembolism - drug therapy
- Find related publications in this database (Keywords)
- hypertension, pulmonary
- endarterectomy
- chronic disease