Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Fried, I; Cerroni, L.
FOXP3 in sequential biopsies of progressive mycosis fungoides.
Am J Dermatopathol. 2012; 34(3):263-265
Doi: 10.1097/DAD.0b013e31823062db
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Cerroni Lorenzo
- Fried Isabella
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- Abstract:
- A recent report has suggested that the numbers of regulatory T cells correlate with stage of disease and prognosis in mycosis fungoides (MF). To evaluate the role of FOXP3+ Tregs in different stages of MF, we investigated sequential biopsies in 14 patients with patch/plaque and subsequent tumor stage using FOXP3 antibody. Our data neither show a significant difference in the percentage of FOXP3+ cells between patch/plaque and tumor stage biopsies of MF nor demonstrate a predictable shift of Tregs in the course of disease progression. Additionally, we could observe FOXP3-expressing neoplastic cells in 4 patch/plaque stage biopsies, where they represented almost 100% of the epidermotropic infiltrate. Only in one of these patients, FOXP3+ cells could also be detected in the tumor stage biopsy, indicating that FOXP3 expression can be acquired or lost during the course of the disease, comparable to other phenotypic markers.
- Find related publications in this database (using NLM MeSH Indexing)
- Cell Count -
- Disease Progression -
- Forkhead Transcription Factors - metabolism
- Humans -
- Mycosis Fungoides - diagnosis
- Skin Neoplasms - diagnosis
- T-Lymphocytes, Regulatory - immunology
- Tumor Markers, Biological - metabolism
- Find related publications in this database (Keywords)
- mycosis fungoides
- regulatory T cells
- FOXP3