Medizinische Universität Graz - Research portal
Selected Publication:
Evangelista, S; Lippe, IT; Rovero, P; Maggi, CA; Meli, A.
Tachykinins protect against ethanol-induced gastric lesions in rats.
Peptides. 1989; 10(1):79-81
Doi: 10.1016/0196-9781(89)90080-6
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- Co-authors Med Uni Graz
- Lippe Irmgard Theresia
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- Abstract:
- Subcutaneous pretreatment of rats with neurokinin (NK) A or the fragment NKA(4-10) reduced the degree of gastric lesions induced by oral administration of 96% ethanol. The protective effect of NKA(4-10) was dose-dependent. Arg-NKB, the water soluble derivative of NKB, was less effective than NKA or NKA(4-10) while [Me-Phe7]NKB, substance P (SP) and SP-methyl-ester were inactive. The NKA(4-10) antilesion effect was reversed by pretreatment with N-ethyl-maleimide, suggesting a possible involvement of sulphydryls in its action. Among the nonmammalian tachykinins, kassinin significantly reduced ethanol-induced lesions while eledoisin and physalaemin at equivalent molar doses were inactive. These results provide, for the first time, evidence that tachykinins and their derivatives exert gastroprotective activity toward ethanol-induced haemorrhagic lesions. Assuming a receptor-mediated mechanism, NK-2 sites could be involved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Ethanol - antagonists and inhibitors
- Ethylmaleimide - pharmacology
- Indomethacin - pharmacology
- Male - pharmacology
- Rats - pharmacology
- Rats, Inbred Strains - pharmacology
- Stomach - drug effects
- Tachykinins - pharmacology