Medizinische Universität Graz - Research portal
Selected Publication:
Donnerer, J.
Primary sensory neurones and naloxone-precipitated morphine withdrawal.
Br J Pharmacol. 1989; 96(4):767-772
Doi: 10.1111/j.1476-5381.1989.tb11881.x
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Leading authors Med Uni Graz
- Donnerer Josef
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- 1. The C-fibre-evoked depressor reflex following i.a. injection of capsaicin and the wiping movements following chemical irritation of the cornea by capsaicin were both found to be augmented in the naloxone-precipitated morphine withdrawal phase. 2. The in vitro capsaicin-evoked release of substance P from central terminals of C-fibre afferents in the spinal cord was decreased in morphine-treated rats. Following naloxone, the release in the morphine-treated group was as large as in the control group. 3. The C-fibre mediated plasma extravasation in the rat paw after naloxone was found to be the same in morphine-treated and control rats. 4. It is concluded that C-fibre-evoked reflex reactions are augmented during morphine withdrawal, but that the mechanisms responsible are either located postsynaptically to the primary sensory neurone or further centrally.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blood Pressure - drug effects
- Capsaicin - pharmacology
- Female - pharmacology
- Male - pharmacology
- Morphine Dependence - physiopathology
- Naloxone - pharmacology
- Nerve Fibers - drug effects
- Neurons, Afferent - drug effects
- Rats - drug effects
- Rats, Inbred Strains - drug effects
- Reflex - drug effects
- Substance P - pharmacology
- Substance Withdrawal Syndrome - physiopathology
- Time Factors - physiopathology