Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gauster, M; Desoye, G; Tötsch, M; Hiden, U.
The placenta and gestational diabetes mellitus.
Curr Diab Rep. 2012; 12(1): 16-23.
Doi: 10.1007/s11892-011-0244-5
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Desoye Gernot
- Gauster Martin
- Co-Autor*innen der Med Uni Graz
- Hiden Ursula
- Tötsch Martin
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- Abstract:
- By its location between maternal and fetal bloodstreams the human placenta not only handles the materno-fetal transport of nutrients and gases, but may also be exposed to intrauterine conditions adversely affecting placental and fetal development. Such adverse conditions exist in pregnancies complicated by gestational diabetes mellitus (GDM), and have been associated with alterations in placental anatomy and physiology. These alterations are mainly based on changes on the micro-anatomical and/or even molecular level including aberrant villous vascularization, a disbalance of vasoactive molecules, and enhanced oxidative stress. The consequence thereof may be impaired fetal oxygenation and changes in transplacental nutrient supply. Although transplacental glucose flux is flow limited and independent of glucose transporter availability, transport of essential and nonessential amino acids and expression of genes involved in lipid transport and metabolism are significantly affected by GDM.
- Find related publications in this database (using NLM MeSH Indexing)
- Birth Weight -
- Blood Glucose - metabolism
- Diabetes, Gestational - metabolism Diabetes, Gestational - physiopathology
- Female -
- Fetal Growth Retardation - etiology Fetal Growth Retardation - metabolism
- Humans -
- Obesity - metabolism Obesity - physiopathology
- Organ Size -
- Oxidative Stress -
- Placenta - metabolism Placenta - pathology Placenta - physiopathology
- Prediabetic State - metabolism Prediabetic State - physiopathology
- Pregnancy -
- Pregnancy, High-Risk -
- Find related publications in this database (Keywords)
- Placenta
- Gestational diabetes mellitus
- Pregnancy pathology
- Angiogenesis
- Placental vascularization
- Placenta development
- Placental blood flow
- Fetal oxygenation
- Oxidative stress
- Inflammation
- Transplacental nutrient supply