Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fröhlich, RF; Fantur, K; Furneaux, RH; Paschke, E; Stütz, AE; Wicki, J; Withers, SG; Wrodnigg, TM.
A fluorescent probe for GM1 gangliosidosis related â-galactosidase: N-(dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-D-galactitol.
Bioorg Med Chem Lett. 2011; 21(22):6872-6875
Doi: 10.1016/j.bmcl.2011.09.012
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Fantur Katrin Medea-Emma
- Paschke Eduard
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- Abstract:
- N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-D-galactitol, a strong competitive inhibitor of â-galactosidase, enhances residual â-galactosidase activities in fibroblasts and serves as lead en route to diagnostic compounds for tracking the fate of mutant â-gal as well as aberrant GM1 gangliosides by live cell imaging.
Copyright © 2011 Elsevier Ltd. All rights reserved. - Find related publications in this database (using NLM MeSH Indexing)
- Agrobacterium - enzymology
- Escherichia coli - enzymology
- Fibroblasts - cytology
- Fluorescent Dyes - chemistry
- Galactitol - chemistry
- Gangliosidosis, GM1 - diagnosis
- Humans -
- Lysosomal-Associated Membrane Protein 2 - analysis
- Microscopy, Fluorescence -
- Mutation -
- beta-Galactosidase - analysis
- Find related publications in this database (Keywords)
- Iminoalditols
- D-Galactosidase inhibitor
- GM1 gangliosidosis
- Pharmacological chaperone
- Fluorescent probe