Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bernhardt, GA; Zollner, G; Cerwenka, H; Kornprat, P; Fickert, P; Bacher, H; Werkgartner, G; Müller, G; Zatloukal, K; Mischinger, HJ; Trauner, M.
Hepatobiliary transporter expression and post-operative jaundice in patients undergoing partial hepatectomy.
Liver Int. 2012; 32(1):119-127
Doi: 10.1111/j.1478-3231.2011.02625.x
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Bernhardt Gerwin
- Co-Autor*innen der Med Uni Graz
- Bacher Heinz
- Cerwenka Herwig
- Fickert Peter
- Kornprat Peter
- Mischinger Hans-Jörg
- Trauner Michael
- Werkgartner Georg
- Zatloukal Kurt
- Zollner Gernot
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- Abstract:
- Post-operative hyperbilirubinaemia in patients undergoing liver resections is associated with high morbidity and mortality. Apart from different known factors responsible for the development of post-operative jaundice, little is known about the role of hepatobiliary transport systems in the pathogenesis of post-operative jaundice in humans after liver resection. Two liver tissue samples were taken from 14 patients undergoing liver resection before and after Pringle manoeuvre. Patients were retrospectively divided into two groups according to post-operative bilirubin serum levels. The two groups were analysed comparing the results of hepatobiliary transporter [Na-taurocholate cotransporter (NTCP); multidrug resistance gene/phospholipid export pump(MDR3); bile salt export pump (BSEP); canalicular bile salt export pump (MRP2)], heat shock protein 70 (HSP70) expression as well as the results of routinely taken post-operative liver chemistry tests. Patients with low post-operative bilirubin had lower levels of NTCP, MDR3 and BSEP mRNA compared to those with high bilirubin after Pringle manoeuvre. HSP70 levels were significantly higher after ischaemia-reperfusion (IR) injury in both groups resulting in 4.5-fold median increase. Baseline median mRNA expression of all four transporters prior to Pringle manoeuvre tended to be lower in the low bilirubin group whereas expression of HSP70 was higher in the low bilirubin group compared to the high bilirubin group. Higher mRNA levels of HSP70 in the low bilirubin group could indicate a possible protective effect of high HSP70 levels against IR injury. Although the exact role of hepatobiliary transport systems in the development of post-operative hyper bilirubinemia is not yet completely understood, this study provides new insights into the molecular aspects of post-operative jaundice after liver surgery. © 2011 John Wiley & Sons A/S.
- Find related publications in this database (using NLM MeSH Indexing)
- ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism
- Aged -
- Bilirubin - blood
- Carrier Proteins - genetics Carrier Proteins - metabolism
- Female -
- Gene Expression -
- HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism
- Hepatectomy -
- Humans -
- Jaundice - genetics Jaundice - metabolism Jaundice - pathology
- Liver Function Tests -
- Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - secondary
- Male -
- Middle Aged -
- Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - metabolism
- Organic Anion Transporters, Sodium-Dependent - genetics Organic Anion Transporters, Sodium-Dependent - metabolism
- P-Glycoproteins - genetics P-Glycoproteins - metabolism
- Postoperative Complications -
- Retrospective Studies -
- Symporters - genetics Symporters - metabolism
- Find related publications in this database (Keywords)
- cholestasis
- hepatectomy
- hepatobiliary transporter system
- ischaemia-reperfusion injury
- liver proteins
- liver surgery
- post-operative jaundice
- Pringle manoeuvre