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SHR Neuro Cancer Cardio Lipid Metab Microb
Bock, G; Prietl, B; Mader, JK; Höller, E; Wolf, M; Pilz, S; Graninger, WB; Obermayer-Pietsch, BM; Pieber, TR.
The effect of vitamin D supplementation on peripheral regulatory T cells and β cell function in healthy humans: a randomized controlled trial.
Diabetes Metab Res Rev. 2011; 27(8):942-945
Doi: 10.1002/dmrr.1276
Web of Science
PubMed
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FullText_MUG
- Leading authors Med Uni Graz
- Treiber Gerlies
- Co-authors Med Uni Graz
- Graninger Winfried
- Lechner Evelyne
- Mader Julia
- Obermayer-Pietsch Barbara
- Pieber Thomas
- Pilz Stefan
- Prietl Barbara
- Wolf Michael
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- Abstract:
- Increasing evidence supports the role of vitamin D (vitD) in modifying the risk to develop type 1 diabetes (T1D) and other autoimmune diseases. VitD3 might stimulate regulatory T cells (Tregs), a central player in the maintenance of self-tolerance. In addition, direct effects of vitD on β-cell function are postulated. The aim of our study was to evaluate the effect of a high dose vitD supplementation on Tregs frequency (%Tregs) and β-cell function assessed by a mixed meal tolerance test (MMTT) in healthy humans. A double-blind, placebo controlled trial was performed in 59 healthy adult subjects (49% females). Subjects received oral vitD3 (140,000 IU monthly) or placebo for 3 months. %Tregs within 20,000 CD4+ T cells of peripheral blood was determined by multi-parametric FACS-analysis. A liquid MMTT was carried out before and after treatment. %Tregs increased significantly in the vitD group, but remained unchanged in the placebo group. Fasting C-peptide concentrations did not change significantly in either group. Similarly, the mean AUC for C-peptide after 3 months and the change in mean values from baseline to the end of the treatment were comparable in both groups. A short time high dose vitD3 supplementation significantly increased the frequency of Tregs, but did not further improve β-cell function in apparently healthy subjects. The immunomodulatory potential of vitD might be an important mechanistic link for the association of vitD and T1D. Copyright © 2011 John Wiley & Sons, Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- C-Peptide - blood
- Cholecalciferol - administration & dosage Cholecalciferol - therapeutic use
- Dietary Supplements -
- Double-Blind Method -
- Female -
- Humans -
- Immunomodulation - drug effects Immunomodulation - physiology
- Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - physiology
- T-Lymphocytes, Regulatory - drug effects
- Find related publications in this database (Keywords)
- vitamin D
- beta cell function
- vitamin D supplementation
- regulatory T cells