Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tomaschitz, A; Pilz, S; Ritz, E; Grammer, T; Amrein, K; Merger, S; Meinitzer, A; Winkelmann, BR; Boehm, BO; März, W.
Relationship between plasma aldosterone concentration and soluble cellular adhesion molecules in patients referred to coronary angiography.
Exp Clin Endocrinol Diabetes. 2011; 119(10): 649-655.
Doi: 10.1055/s-0031-1287791
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Tomaschitz Andreas
- Co-Autor*innen der Med Uni Graz
- Amrein Karin
- März Winfried
- Meinitzer Andreas
- Pilz Stefan
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- Abstract:
- OBJECTIVE: Evidence is emerging that aldosterone contributes to the development and progression of atherosclerosis and cardiovascular disease. Little is known, however, regarding an association between circulating aldosterone levels and soluble cellular adhesion molecules in humans. METHODS: We investigated the relationship between plasma aldosterone concentration (PAC) and soluble cellular adhesion molecules in a large cohort of patients referred to coronary angiography. After exclusion of patients with ongoing mineralocorticoid receptor blocker use, oral contraceptive or hormone replacement therapy, 1,733 patients (mean age: 62.5±10.8 years; 26.4%% women; mean PAC: 101.5±93.5âpg/mL) remained eligible for analyses. RESULTS: Pearson correlation analysis as well as age and gender adjusted partial correlation analysis revealed a positive association between PAC and soluble (s) E-, L- and P-selectin levels but not with sICAM-1 and sVCAM-1, respectively. In multivariate adjusted analyses of covariance (ANCOVA) sE- (p=0.026), sL- (p=0.049) and sP-selectin (p<0.001) levels increased steadily from the first (reference) to the third gender-specific tertile of PAC. No significant variation across PAC tertiles was found for sICAM-1 (p=0.767) and sVCAM1 (p=0.425) levels, respectively. Finally, multivariate regression analyses revealed circulating aldosterone as an important predictor for soluble selectin levels. CONCLUSION: Our findings in a large cohort of patients indicate that upregulation of selectins might represent a novel mechanism of aldosterone mediated development and progression of atherosclerosis. In view of aldosterone as a novel cardiovascular risk factor independent of angiotensin II, our findings warrant further interventional studies which should evaluate anti-atherosclerotic effects of aldosterone blocking treatment strategies in humans.
© J. A. Barth Verlag in George Thieme Verlag KG Stuttgart · New York. - Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aldosterone - blood
- Atherosclerosis - blood
- Cohort Studies -
- Coronary Angiography -
- E-Selectin - blood
- E-Selectin - epidemiology
- Female -
- Heart Failure - blood
- Humans -
- Intercellular Adhesion Molecule-1 - blood
- L-Selectin - blood
- Male -
- Middle Aged -
- Models, Biological -
- P-Selectin - blood
- Prevalence -
- Risk Factors -
- Severity of Illness Index -
- Solubility -
- Up-Regulation -
- Vascular Cell Adhesion Molecule-1 - blood
- Find related publications in this database (Keywords)
- plasma aldosterone
- soluble cellular adhesion molecules