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SHR Neuro Cancer Cardio Lipid Metab Microb
Hector, A; Kormann, MS; Mack, I; Latzin, P; Casaulta, C; Kieninger, E; Zhou, Z; Yildirim, AÖ; Bohla, A; Rieber, N; Kappler, M; Koller, B; Eber, E; Eickmeier, O; Zielen, S; Eickelberg, O; Griese, M; Mall, MA; Hartl, D.
The chitinase-like protein YKL-40 modulates cystic fibrosis lung disease.
PLoS One. 2011; 6(9):e24399-e24399
Doi: 10.1371/journal.pone.0024399
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- Co-authors Med Uni Graz
- Eber Ernst
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- Abstract:
- The chitinase-like protein YKL-40 was found to be increased in patients with severe asthma and chronic obstructive pulmonary disease (COPD), two disease conditions featuring neutrophilic infiltrates. Based on these studies and a previous report indicating that neutrophils secrete YKL-40, we hypothesized that YKL-40 plays a key role in cystic fibrosis (CF) lung disease, a prototypic neutrophilic disease. The aim of this study was (i) to analyze YKL-40 levels in human and murine CF lung disease and (ii) to investigate whether YKL-40 single-nucleotide polymorphisms (SNPs) modulate CF lung disease severity. YKL-40 protein levels were quantified in serum and sputum supernatants from CF patients and control individuals. Levels of the murine homologue BRP-39 were analyzed in airway fluids from CF-like βENaC-Tg mice. YKL-40SNPs were analyzed in CF patients. YKL-40 levels were increased in sputum supernatants and in serum from CF patients compared to healthy control individuals. Within CF patients, YKL-40 levels were higher in sputum than in serum. BRP-39 levels were increased in airways fluids from βENaC-Tg mice compared to wild-type littermates. In both CF patients and βENaC-Tg mice, YKL-40/BRP-39 airway levels correlated with the severity of pulmonary obstruction. Two YKL-40 SNPs (rs871799 and rs880633) were found to modulate age-adjusted lung function in CF patients. YKL-40/BRP-39 levelsare increased in human and murine CF airway fluids, correlate with pulmonary function and modulate CF lung disease severity genetically. These findings suggest YKL-40 as a potential biomarker in CF lung disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipokines - blood
- Adipokines - genetics
- Adipokines - metabolism
- Animals -
- Chitinase-3-Like Protein 1 -
- Cystic Fibrosis - genetics
- Cystic Fibrosis - metabolism
- Cystic Fibrosis - pathology
- Female -
- Humans -
- Lectins - blood
- Lectins - genetics
- Lectins - metabolism
- Male -
- Mice -
- Polymorphism, Single Nucleotide -
- Sputum - metabolism
- Young Adult -