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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Prüller, F; Raggam, RB; Posch, V; Almer, G; Truschnig-Wilders, M; Horejsi, R; Möller, R; Weghuber, D; Ille, R; Schnedl, W; Mangge, H.
Trunk weighted obesity, cholesterol levels and low grade inflammation are main determinants for enhanced thrombin generation.
Atherosclerosis. 2012; 220(1):215-218
Doi: 10.1016/j.atherosclerosis.2011.09.035
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Mangge Harald
- Prüller Florian
- Co-authors Med Uni Graz
- Almer Gunter
- Horejsi Renate
- Ille Rottraut
- Möller Reinhard
- Raggam Reinhard Bernd
- Schnedl Wolfgang
- Truschnig-Wilders Martini
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- Abstract:
- Endogenous thrombin generation (ETP) may be critically involved in obesity associated thromboembolism. Three hundred and one participants of the STyrian Juvenile OBesity (STYJOBS)/Early DEteCTion of Atherosclerosis (EDECTA) study cohort (age, 16-58years) were analysed. ETP was measured by the new CE-IVD marked Siemens-Innovance(®) ETP test on a BCS-XP analyser, and correlated to clinical findings and extended lipometry-based anthropometric data, biomarkers, and coagulation parameters. In the overweight/obese study group, ETP and fibrinogen levels were significantly higher compared to controls (p<0.001). In a multiple stepwise regression including all subjects, subcutaneous adipose tissue thickness of upper back, cholesterol and ultrasensitive C-reactive protein were the best predictors for ETP. Trunk weighted obesity together with low grade inflammation and hypercholesterolemia enhance thrombin generation. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Analysis of Variance -
- Analysis of Variance -
- Biomarkers - blood
- Blood Coagulation -
- Body Mass Index -
- C-Reactive Protein - analysis
- Case-Control Studies -
- Cholesterol - blood
- Female -
- Fibrinogen - analysis
- Humans -
- Hypercholesterolemia - blood
- Hypercholesterolemia - complications
- Inflammation - blood
- Inflammation - complications
- Inflammation Mediators - blood
- Male -
- Middle Aged -
- Obesity - blood
- Obesity - complications
- Obesity - pathology
- Prospective Studies -
- Regression Analysis -
- Risk Assessment -
- Risk Factors -
- Subcutaneous Fat - pathology
- Thrombin - analysis
- Thromboembolism - blood
- Thromboembolism - etiology
- Young Adult -
- Find related publications in this database (Keywords)
- Endogenous thrombin potential (ETP)
- Trunk obesity
- Low grade inflammation
- Thrombosis risk