Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Crnkovic, S; Hrzenjak, A; Marsh, LM; Olschewski, A; Kwapiszewska, G.
Origin of neomuscularized vessels in mice exposed to chronic hypoxia.
Respir Physiol Neurobiol. 2011; 179(2-3):342-345
Doi: 10.1016/j.resp.2011.09.016
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Crnkovic Slaven
- Kwapiszewska-Marsh Grazyna
- Co-Autor*innen der Med Uni Graz
- Hrzenjak Andelko
- Marsh Leigh
- Olschewski Andrea
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- Abstract:
- Exposure of mice to chronic hypoxia is one of the most often used animal models to study pulmonary hypertension. Hypoxia exposure leads to vascular remodeling and muscularization of the small parenchymal vessels in the lung. Due to the anatomical differences between mice and humans, it is not possible to determine whether the remodeled vessels originate from the arterial or venous side of the vasculature. By applying antibodies against specific marker molecules expressed by arterial (ephrinB2) and venous (EphB4) endothelial cells, we could show that remodeled parenchymal vessels in hypoxia-exposed mice are mostly of arterial origin with slight venous involvement. Using these tools, it is possible to further characterize remodeled vessels in other small animal models, such as transgenic or knockout mice. Particularly useful applications would include selection of parenchymal vessels for laser microdissection studies. Copyright © 2011 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Airway Remodeling - physiology
- Animals -
- Arteries - metabolism
- Biomarkers - analysis
- Chronic Disease -
- Disease Models, Animal -
- Ephrins - analysis
- Ephrins - metabolism
- Hypertension, Pulmonary - etiology
- Hypertension, Pulmonary - metabolism
- Hypertension, Pulmonary - pathology
- Hypoxia - complications
- Hypoxia - pathology
- Immunohistochemistry -
- Lung - blood supply
- Lung - pathology
- Male -
- Mice -
- Neovascularization, Pathologic - etiology
- Neovascularization, Pathologic - pathology
- Veins - metabolism
- Find related publications in this database (Keywords)
- Chronic hypoxia
- Pulmonary vascular remodeling
- EphrinB2
- EphB4