Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pilz, S; Kienreich, K; Drechsler, C; Ritz, E; Fahrleitner-Pammer, A; Gaksch, M; Meinitzer, A; März, W; Pieber, TR; Tomaschitz, A.
Hyperparathyroidism in patients with primary aldosteronism: cross-sectional and interventional data from the GECOH study.
J Clin Endocrinol Metab. 2012; 97(1):E75-9
Doi: 10.1210/jc.2011-2183
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- Führende Autor*innen der Med Uni Graz
- Pilz Stefan
- Tomaschitz Andreas
- Co-Autor*innen der Med Uni Graz
- Fahrleitner-Pammer Astrid
- Keppel Martin Helmut
- Kienreich Katharina
- März Winfried
- Meinitzer Andreas
- Pieber Thomas
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- Abstract:
- CONTEXT: Experimental studies suggest that aldosterone induces hypercalciuria and might contribute to hyperparathyroidism. OBJECTIVE: We aimed to test for differences in PTH levels and parameters of calcium and vitamin D metabolism in patients with primary aldosteronism (PA) compared with patients with essential hypertension (EH) and to evaluate the impact of PA treatment on these laboratory values. DESIGN, SETTING, AND PARTICIPANTS: The Graz Endocrine Causes of Hypertension study includes hypertensive patients referred for screening for endocrine hypertension at a tertiary care center in Graz, Austria. MAIN OUTCOME MEASURES: Differences in PTH levels between patients with PA and EH. RESULTS: Among 192 patients, we identified 10 patients with PA and 182 with EH. PTH levels (mean ± sd in picograms per milliliter) were significantly higher in PA patients compared with EH (67.8 ± 26.9 vs. 46.5 ± 20.9; P = 0.002). After treatment of PA with either adrenal surgery (n = 5) or mineralocorticoid receptor antagonists (n = 5), PTH concentrations decreased to 43.9 ± 14.9 (P = 0.023). Serum 25-hydroxyvitamin D concentrations were similar in both groups. Compared with EH, serum calcium concentrations were significantly lower (2.35 ± 0.10 vs. 2.26 ± 0.10 mmol/liter; P = 0.013), and there was a nonsignificant trend toward an increased spot urine calcium to creatinine ratio in PA [median (interquartile range) 0.19 (0.11-0.31) vs. 0.33 (0.12-0.53); P = 0.094]. CONCLUSIONS: Our results suggest that PA contributes to secondary hyperparathyroidism. Further studies are warranted to evaluate whether PTH has implications for PA diagnostics and whether mineralocorticoid receptor antagonists have a general impact on PTH and calcium metabolism.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Aged - administration & dosage
- Aldosterone - blood
- Blood Pressure - physiology
- Clinical Trials as Topic - statistics & numerical data
- Cross-Sectional Studies - administration & dosage
- Data Interpretation, Statistical - administration & dosage
- Female - administration & dosage
- Follow-Up Studies - administration & dosage
- Humans - administration & dosage
- Hyperaldosteronism - blood, complications, physiopathology, therapy
- Hyperparathyroidism - blood, complications, physiopathology, therapy
- Hypertension - blood, complications, etiology, physiopathology, therapy
- Male - administration & dosage
- Middle Aged - administration & dosage
- Parathyroid Hormone - blood
- Renin-Angiotensin System - physiology