Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Antoons, G; Sipido, KR.
Targeting calcium handling in arrhythmias.
Europace. 2008; 10(12):1364-1369
Doi: 10.1093/europace/eun271
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- Leading authors Med Uni Graz
- Antoons Gudrun
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- Abstract:
- Abnormal calcium (Ca) handling can contribute to arrhythmogenesis directly by triggering abnormal depolarizations and indirectly by modulating action potential time course and duration. Recent data have shown the importance of these mechanisms in rare genetic diseases but also in more common conditions such as heart failure. Modulating Ca release from the sarcoplasmic reticulum via the ryanodine receptor, Ca uptake via sarcoplasmic reticulum Ca ATPase or Ca removal from the cell via the Na/Ca exchanger, are potential approaches to reduce arrhythmias. New tools allow exploring these ideas. The principles underlying this approach and the first results are critically reviewed.
- Find related publications in this database (using NLM MeSH Indexing)
- Anti-Arrhythmia Agents - administration and dosage
- Arrhythmias, Cardiac - drug therapy Arrhythmias, Cardiac - metabolism
- Calcium - metabolism
- Calcium Channels - metabolism
- Drug Delivery Systems - methods
- Humans -
- Ion Channel Gating - drug effects
- Models, Cardiovascular -
- Find related publications in this database (Keywords)
- Calcium
- Cardiac myocyte
- Sarcoplasmic reticulum
- Na/Ca exchange
- Arrhythmias
- Ryanodine receptor
- SERCA