Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stein, M; Noorman, M; van Veen, TA; Herold, E; Engelen, MA; Boulaksil, M; Antoons, G; Jansen, JA; van Oosterhout, MF; Hauer, RN; de Bakker, JM; van Rijen, HV.
Dominant arrhythmia vulnerability of the right ventricle in senescent mice.
Heart Rhythm. 2008; 5(3): 438-448.
Doi: 10.1016/j.hrthm.2007.10.033
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Antoons Gudrun
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- Abstract:
- BACKGROUND Several cardiac disorders affect the right ventricle (RV) and Left ventricle (LV) equally, but nevertheless, RV vulnerability to conduction stowing and arrhythmias exceeds that of the LV. OBJECTIVE This study sought to assess the mechanism of dominant RV arrhythmia vulnerability in senescent mice as a model of general reduced myocardial integrity. METHODS Epicardial ventricular activation mapping was performed on senescent (22 months) and adult (3 months) Langendorff perfused mouse hearts. Arrhythmia inducibility was tested by programmed stimulation. Conduction velocity longitudinal and transversal (CVT) to fiber orientation, conduction heterogeneity, and effective refractory period were determined. Subsequently, hearts were processed for immunohistochemistry, Western blotting, and Sirius red staining. RESULTS In senescent RV, but not LV, CVT was reduced and wavelength decreased, whereas anisotropic ratio and conduction heterogeneity increased. Arrhythmias, based on anisotropic reentry, were induced in 55% of senescent hearts only and predominantly in RV. In senescent mice, Connexin 43 (Cx43) and Cardiac Sodium Channel (Nav1.5) were decreased and interstitial fibrosis increased comparably in RV and LV. However, in senescent mice, heterogeneously distributed patches of replacement fibrosis were present throughout the entire RV myocardium, but only in midendocardium and subendocardiurn of LV. Cx43 expression in these areas was disrupted. CONCLUSION Widespread presence of replacement fibrosis in senescent RV compared with LV, combined with Cx43 and Nav1.5 disruption, potentiate shorter wavelength, conduction stowing, and conduction heterogeneity in RV, resulting in greater vulnerability of senescent RV to arrhythmias.
- Find related publications in this database (using NLM MeSH Indexing)
- Aging - physiology
- Analysis of Variance -
- Animals -
- Arrhythmias, Cardiac - physiopathology
- Blotting, Western -
- Echocardiography, Doppler -
- Electrocardiography -
- Fibrosis -
- Heart Conduction System - physiopathology
- Heart Ventricles - physiopathology
- Immunohistochemistry -
- Linear Models -
- Mice -
- Mice, Inbred C57BL -
- Find related publications in this database (Keywords)
- tachyarrhythmia
- conduction
- collagen
- gap junction
- mapping