Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
D'Hooge, R; De Deyn, PP; Van de Vijver, G; Antoons, G; Raes, A; Van Bogaert, PP.
Uraemic guanidino compounds inhibit gamma-aminobutyric acid-evoked whole cell currents in mouse spinal cord neurones.
Neurosci Lett. 1999; 265(2):83-86
Doi: 10.1016/S0304-3940(99)00190-1
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- Co-Autor*innen der Med Uni Graz
- Antoons Gudrun
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- Abstract:
- Guanidine, creatinine (CTN), methylguanidine (MG) and guanidinosuccinic acid (GSA) are four endogenous guanidino compounds with proven neuroexcitatory actions, and putative pathophysiological significance as uraemic toxins. The effects of these uraemic guanidino compounds, were studied on whole-cell current evoked by gamma-amino butyric acid (GABA) on mouse spinal cord neurones in vitro. CTN, MG and GSA concentration dependently blocked GABA-evoked current with calculated IC50 values (+/-SE) of 9.6 +/- 0.9, 9.7 +/- 1.5 and 5.1 +/- 0.4 mM, respectively. CTN, MG and GSA were shown to block inward and outward currents to the same extent, demonstrating voltage independent block of GABA-evoked current by these compounds. Guanidine, however, evoked inward whole-cell currents, which were almost completely blocked by strychnine, indicating that the guanidine-evoked current might have been due to glycine receptor activation.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cells, Cultured -
- Creatinine - pharmacology
- Electric Conductivity -
- Electrophysiology -
- Guanidines - metabolism Guanidines - pharmacology
- Methylguanidine - pharmacology
- Mice -
- Neurons - drug effects Neurons - physiology
- Osmolar Concentration -
- Spinal Cord - cytology Spinal Cord - drug effects Spinal Cord - physiology
- Succinates - pharmacology
- Uremia - metabolism
- gamma-Aminobutyric Acid - pharmacology
- Find related publications in this database (Keywords)
- gamma-aminobutyric acid
- whole cell currents
- guanidino compounds