Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Schrama, D; Becker, JC.
Merkel cell carcinoma--pathogenesis, clinical aspects and treatment.
J Eur Acad Dermatol Venereol. 2011; 25(10):1121-1129
Doi: 10.1111/j.1468-3083.2011.04032.x
Web of Science
PubMed
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FullText_MUG
- Leading authors Med Uni Graz
- Becker Jürgen Christian
- Schrama David
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- Abstract:
- Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine carcinoma of the skin demonstrating a high rate of recurrence and metastasis. Indeed, 5-year rates for MCC specific survival are only about 60%. Although MCCs' incidence is rapidly increasing, it is still a very rare tumour. In this regard, the American Cancer Society had estimated for 2008 almost 1500 new cases in the USA. Recently, the newly identified Merkel cell polyomavirus has been found associated with most of the MCC cases. Nevertheless, the pathogenesis of MCC is not yet fully understood. Here, we will summarize recent findings of the pathogenesis of MCC, present an overview of clinical aspects and discuss treatment options for MCCs.
© 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology. - Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma, Merkel Cell - etiology
- Humans -
- Merkel cell polyomavirus - isolation and purification
- Prevalence -
- Skin - pathology
- Skin Neoplasms - etiology