Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Khalil, M; Langkammer, C; Ropele, S; Petrovic, K; Wallner-Blazek, M; Loitfelder, M; Jehna, M; Bachmaier, G; Schmidt, R; Enzinger, C; Fuchs, S; Fazekas, F.
Determinants of brain iron in multiple sclerosis: a quantitative 3T MRI study.
Neurology. 2011; 77(18): 1691-1697.
Doi: 10.1212/WNL.0b013e318236ef0e
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Fazekas Franz
- Khalil Michael
- Co-Autor*innen der Med Uni Graz
- Bachmaier Gerhard
- Enzinger Christian
- Fuchs Siegrid
- Jehna Margit
- Koini Marisa
- Langkammer Christian
- Petrovic Katja-Elisabeth
- Ropele Stefan
- Schmidt Reinhold
- Wallner-Blazek Mirja
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- Abstract:
- Objectives: Abnormal high cerebral iron deposition may be implicated in chronic neurologic disorders, including multiple sclerosis (MS). R2* relaxometry has been recently validated in a postmortem study to indicate brain iron accumulation in a quantitative manner. We used this technique to assess brain iron levels in different stages of MS and healthy controls (HC) and determined their relation with demographic, clinical, neuropsychological, and other imaging variables. Methods: We studied 113 consecutive patients (35 clinically isolated syndrome [CIS], 78 MS) and 35 HC with 3 T MRI and clinical and neuropsychological examination. Iron deposition in subcortical gray matter structures was assessed by automated, regional calculation of R2* rates. Results: Basal ganglia (BG) R2* levels were significantly increased in MS compared to CIS (p < 0.001) and HC (p < 0.005). They were correlated with age (r = 0.5, p < 0.001), disease duration (r = 0.5, p < 0.001), Expanded Disability Status Scale (r = 0.3, p < 0.005), and the z values of mental processing speed (r = -0.3, p < 0.01). Stepwise linear regression analysis revealed gray matter atrophy as the strongest independent predictor of BG R2* levels (p < 0.001), followed by age (p < 0.001) and T2 lesion load (p < 0.005). Conclusion: BG iron accumulation in MS occurs with advancing disease and is related to the extent of morphologic brain damage, which argues for iron deposition as an epiphenomenon. The absence of increased iron levels in patients with CIS indicates that iron accumulation does not precede the development of MS. Neurology(R) 2011;77:1691-1697
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Brain - anatomy and histology Brain - metabolism Brain - pathology
- Female -
- Humans -
- Iron - metabolism
- Magnetic Resonance Imaging - methods
- Male -
- Middle Aged -
- Multiple Sclerosis - pathology Multiple Sclerosis - physiopathology
- Neuropsychological Tests -
- Young Adult -