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SHR Neuro Cancer Cardio Lipid Metab Microb
Lerchbaum, E; Gruber, HJ; Schwetz, V; Giuliani, A; Möller, R; Pieber, TR; Obermayer-Pietsch, B.
Fatty liver index in polycystic ovary syndrome.
Eur J Endocrinol. 2011; 165(6): 935-943.
Doi: 10.1530/EJE-11-0614
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- Leading authors Med Uni Graz
- Lerchbaum Elisabeth
- Co-authors Med Uni Graz
- Giuliani Albrecht
- Gruber Hans-Jürgen
- Möller Reinhard
- Obermayer-Pietsch Barbara
- Pieber Thomas
- Theiler-Schwetz Verena
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- Abstract:
- INTRODUCTION: Women with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances and might be affected by hepatic steatosis. The fatty liver index (FLI) was developed as a simple and accurate predictor of hepatic steatosis. We aimed to analyze the association of FLI with endocrine and metabolic parameters in a cohort of PCOS and control women. METHODS: FLI was calculated using body mass index (BMI), waist circumference, triglycerides, and gamma-glutamyl transferase in 611 PCOS and 139 BMI-matched control women within the same age range. Elevated FLI was defined as >60. Metabolic, endocrine, and anthropometric measurements and oral glucose tolerance tests were performed. RESULTS: PCOS women had significantly higher FLI levels than control women in age-adjusted analyses (11.4 (4.3-48.8) and 8.8 (3.9-35.0), respectively, P=0.001), whereas fibrosis indices were similar (aspartate amino transferase-to-platelet ratio index) or lower (FIB-4) respectively. In binary logistic regression analysis adjusted for age, odds ratio (OR) for elevated FLI was 2.52 (1.31-4.85), P=0.006, for PCOS women when compared with controls. PCOS women with high FLI levels had an adverse anthropometric, metabolic, and endocrine risk profile. The prevalence of elevated FLI was 88.7% in PCOS women with metabolic syndrome (MS) and 11.3% in PCOS women without MS (P<0.001). In control women, elevated FLI was present in 66.7% of women with MS and 30.8% of women without MS. CONCLUSION: High FLI levels are a common finding in obese PCOS women and are closely linked to MS. FLI calculation might be a useful tool for identifying PCOS patients at high risk for metabolic and hepatic disturbances.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Body Mass Index -
- Fatty Liver - blood
- Female -
- Humans -
- Middle Aged -
- Polycystic Ovary Syndrome - blood
- Triglycerides - blood
- Waist Circumference - physiology
- Young Adult -
- gamma-Glutamyltransferase - blood