Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Maringwa, J; Quinten, C; King, M; Ringash, J; Osoba, D; Coens, C; Martinelli, F; Reeve, BB; Gotay, C; Greimel, E; Flechtner, H; Cleeland, CS; Schmucker-Von Koch, J; Weis, J; Van Den Bent, MJ; Stupp, R; Taphoorn, MJ; Bottomley, A.
Minimal clinically meaningful differences for the EORTC QLQ-C30 and EORTC QLQ-BN20 scales in brain cancer patients.
ANN ONCOL. 2011; 22(9): 2107-2112.
Doi: 10.1093/annonc/mdq726
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- Co-Autor*innen der Med Uni Graz
- Greimel Elfriede Renate
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- Abstract:
- Background: We aimed to determine the smallest changes in health-related quality of life (HRQoL) scores in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core 30 and the Brain Cancer Module (QLQ-BN20), which could be considered as clinically meaningful in brain cancer patients. Materials and methods: World Health Organisation performance status (PS) and mini-mental state examination (MMSE) were used as clinical anchors appropriate to related subscales to determine the minimal clinically important differences (MCIDs) in HRQoL change scores (range 0-100) in the QLQ-C30 and QLQ-BN20. A threshold of 0.2 standard deviation (SD) (small effect) was used to exclude anchor-based MCID estimates considered too small to inform interpretation. Results: Based on PS, our findings support the following integer estimates of the MCID for improvement and deterioration, respectively: physical (6, 9), role (14, 12), and cognitive functioning (8, 8); global health status (7, 4(star)), fatigue (12, 9), and motor dysfunction (4(star), 5). Anchoring with MMSE, cognitive functioning MCID estimates for improvement and deterioration were (11, 2(star)) and for communication deficit were (9, 7). Estimates with asterisks were <0.2 SD and were excluded from our MCID range of 5-14. Conclusion: These estimates can help clinicians evaluate changes in HRQoL over time, assess the value of a health care intervention and can be useful in determining sample sizes in designing future clinical trials.
- Find related publications in this database (using NLM MeSH Indexing)
- Brain Neoplasms - psychology
- Female -
- Humans -
- Male -
- Middle Aged -
- Psychiatric Status Rating Scales -
- Quality of Life -
- Questionnaires -
- Self Report -
- Find related publications in this database (Keywords)
- anchoring
- deterioration
- EORTC QLQ-C30
- health-related quality of life
- improvement
- minimal clinically important difference