Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Mirzaei, S; Bastati, B; Lipp, RW; Knoll, P; Zojer, N; Ludwig, H.
Additional Lesions Detected in Therapeutic Scans with Lu-DOTATATE Reflect Higher Affinity of (177)Lu-DOTATATE for Somatostatin Receptors.
Oncology. 2011; 80(5-6):326-329
Doi: 10.1159/000329808
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Lipp Rainer
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Objective: Peptide receptor-targeted radionuclide therapy (PRRT) of somatostatin receptor (SR)-expressing neuroendocrine tumors (NETs) has become an established therapeutic option in patients with advanced NETs. The aim of this study was to compare the lesion detection rate of (99m)Tc-EDDA/HYNIC-TOC, a newly developed tracer for NET imaging, with (177)Lu-DOTATATE used for PRRT. Methods: 8 patients (4 women, 4 men, age range 46-76 years) with histologically proven NETs, who showed high SR loads by (99m)Tc-EDDA/HYNIC-TOC scintigraphy, were treated with (177)Lu-DOTATATE. After treatment, all patients were subjected to whole-body scintigraphy with additional low-dose single-photon emission computed tomography (SPECT-CT) of the chest and abdomen. Results: All patients demonstrated (177)Lu-DOTATATE accumulation in all lesions previously detected by (99m)TcEDDA/ HYNIC-TOC scintigraphy. Three patients showed additional lesions in the liver and lungs. Conclusions: SPECT-CT after (177)Lu-DOTATATE therapy may be helpful in detecting additional lesions not seen using (99m)Tc-EDDA/HYNIC-TOC. This could reflect the broader affinity of (177)Lu-DOTATATE for SRs compared with (99m)Tc-EDDA/HYNIC-TOC. Copyright (C) 2011 S. Karger AG, Basel
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Bone Neoplasms - metabolism
- Female -
- Humans -
- Liver Neoplasms - metabolism
- Lung Neoplasms - metabolism
- Male -
- Middle Aged -
- Neuroendocrine Tumors - metabolism
- Octreotide - analogs and derivatives
- Organometallic Compounds - diagnostic use
- Organotechnetium Compounds - diagnostic use
- Radiopharmaceuticals - diagnostic use
- Receptors, Somatostatin - metabolism
- Sensitivity and Specificity -
- Time Factors -
- Tomography, Emission-Computed, Single-Photon - methods
- Tomography, X-Ray Computed -
- Find related publications in this database (Keywords)
- Peptide receptor-targeted radionuclide therapy
- SPECT-CT
- (177)Lu-DOTATATE
- (99m)Tc-Tektrotyd
- (99m)Tc-EDDA/HYNIC-TOC
- Neuroendocrine tumors