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SHR Neuro Cancer Cardio Lipid Metab Microb
Roten, L; Derval, N; Sacher, F; Pascale, P; Wilton, SB; Scherr, D; Shah, A; Pedersen, ME; Jadidi, AS; Miyazaki, S; Knecht, S; Hocini, M; Jaïs, P; Haïssaguerre, M.
Ajmaline attenuates electrocardiogram characteristics of inferolateral early repolarization.
Heart Rhythm. 2012; 9(2):232-239
Doi: 10.1016/j.hrthm.2011.09.013
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Scherr Daniel
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- Abstract:
- J waves are the hallmark of both inferolateral early repolarization (ER) and Brugada syndrome. While ajmaline, a class 1a antiarrhythmic drug, accentuates the J wave in Brugada syndrome, its effect on ER is unreported. To describe the effect of ajmaline on the electrocardiogram in ER. We analyzed electrocardiograms before and after the administration of intravenous ajmaline (1 mg/kg) in 31 patients with ER, 21 patients with Brugada type 1 electrocardiogram (Br), and 22 controls. ER was defined as J-point elevation of ≥1 mm with QRS slurring or notching in ≥2 inferolateral leads (I, aVL, II, III, aVF, V4-V6). Ajmaline decreased mean J-wave amplitude in the ER group from 0.2 ± 0.15 mV at baseline to 0.08 ± 0.09 mV (P < .001). The QRS width prolonged significantly in all 3 groups, but the prolongation was significantly less in the ER group (+21 ms) than in the Br group (+36 ms; P < .001) or controls (+28 ms; P = .010). Decrease in mean inferolateral R-wave amplitude was similar in all the groups (ER group -0.14 mV; Br group -0.11 mV; controls -0.13 mV; P = ns), but mean inferolateral S-wave amplitude increased significantly less in the ER group (ER group +0.14 mV; Br group +16 mV; controls +0.20 mV; P < .001). Ajmaline significantly decreases the J-wave amplitude in ER and prolongs the QRS width significantly less than in patients with Br. This indicates a different pathogenesis for both disorders. The altered terminal QRS vector probably is responsible for the decrease in the J-wave amplitude in ER, although a specific effect of ajmaline on J waves cannot be excluded. Copyright © 2012 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Ajmaline - pharmacology
- Ajmaline - therapeutic use
- Anti-Arrhythmia Agents - pharmacology
- Anti-Arrhythmia Agents - therapeutic use
- Brugada Syndrome - drug therapy
- Brugada Syndrome - physiopathology
- Case-Control Studies -
- Electrocardiography - drug effects
- Female -
- Heart Conduction System - drug effects
- Humans -
- Male -
- Find related publications in this database (Keywords)
- Early repolarization
- Brugada syndrome
- J wave
- Ajmaline
- Antiarrhythmic drugs
- Electrocardiogram