Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Seidel, MG; Grohmann, E; Sadeghi, K; Pollak, A; Heitger, A; Förster-Waldl, E.
Vaccination against tick-borne encephalitis virus tests specific IgG production ability in patients under immunoglobulin substitution therapy.
Vaccine. 2010; 28(40):6621-6626 Doi: 10.1016/j.vaccine.2010.07.027
Web of Science PubMed FullText FullText_MUG

Leading authors Med Uni Graz: Seidel Markus
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: To assess B-cell function in patients under immunoglobulin (IgG)-replacement therapy, the non-licensed artificial bacteriophage (ΦX174)-neo-antigen may be used despite limited availability and experience. Active immunization against tick-borne encephalitis (TBE) is performed in few European countries. To test the feasibility of using licensed TBE vaccination as (neo-)antigen to determine residual or restored B-cell function in patients under regular IgG substitution, TBE-IgG levels were analyzed in 18 patients with ≥ 1-2 years of regular intravenous or subcutaneous IgG substitution and in pharmaceutical IgG-preparations (n=21 batches, 10 products). Six individuals were boosted against TBE. Although TBE-specific IgG was detectable in concentrates (281-57,100 VieU/0.5 μL), levels were only borderline in patient sera (n=31, 18 individuals; median 132 VieU; positive >155). Thus, TBE vaccination may be used to test B-cell function under IgG replacement therapy because IgG substitution appears insufficient to yield protective TBE-specific antibody levels in children.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Adult -; Antibodies, Viral - biosynthesis; B-Lymphocytes - immunology; Child -; Child, Preschool -; Encephalitis Viruses, Tick-Borne - immunology; Encephalitis, Tick-Borne - immunology; Feasibility Studies -; Female -; Humans -; Immunization, Passive -; Immunoglobulin G - biosynthesis; Immunologic Deficiency Syndromes - immunology; Male -; Viral Vaccines - immunology; Young Adult -
Find related publications in this database (Keywords): Vaccination in immunodeficiency; IVIG; SCIG; Phi-X 174; Antibody deficiency; Immunodeficiency syndrome; Immunoglobulin substitution/replacement therapy