Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Seidel, MG; Grohmann, E; Sadeghi, K; Pollak, A; Heitger, A; Förster-Waldl, E.
Vaccination against tick-borne encephalitis virus tests specific IgG production ability in patients under immunoglobulin substitution therapy.
Vaccine. 2010; 28(40):6621-6626
Doi: 10.1016/j.vaccine.2010.07.027
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Seidel Markus
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- To assess B-cell function in patients under immunoglobulin (IgG)-replacement therapy, the non-licensed artificial bacteriophage (ΦX174)-neo-antigen may be used despite limited availability and experience. Active immunization against tick-borne encephalitis (TBE) is performed in few European countries. To test the feasibility of using licensed TBE vaccination as (neo-)antigen to determine residual or restored B-cell function in patients under regular IgG substitution, TBE-IgG levels were analyzed in 18 patients with ≥ 1-2 years of regular intravenous or subcutaneous IgG substitution and in pharmaceutical IgG-preparations (n=21 batches, 10 products). Six individuals were boosted against TBE. Although TBE-specific IgG was detectable in concentrates (281-57,100 VieU/0.5 μL), levels were only borderline in patient sera (n=31, 18 individuals; median 132 VieU; positive >155). Thus, TBE vaccination may be used to test B-cell function under IgG replacement therapy because IgG substitution appears insufficient to yield protective TBE-specific antibody levels in children.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Antibodies, Viral - biosynthesis
- B-Lymphocytes - immunology
- Child -
- Child, Preschool -
- Encephalitis Viruses, Tick-Borne - immunology
- Encephalitis, Tick-Borne - immunology
- Feasibility Studies -
- Female -
- Humans -
- Immunization, Passive -
- Immunoglobulin G - biosynthesis
- Immunologic Deficiency Syndromes - immunology
- Male -
- Viral Vaccines - immunology
- Young Adult -
- Find related publications in this database (Keywords)
- Vaccination in immunodeficiency
- IVIG
- SCIG
- Phi-X 174
- Antibody deficiency
- Immunodeficiency syndrome
- Immunoglobulin substitution/replacement therapy