Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kamizono, S; Duncan, GS; Seidel, MG; Morimoto, A; Hamada, K; Grosveld, G; Akashi, K; Lind, EF; Haight, JP; Ohashi, PS; Look, AT; Mak, TW.
Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo.
J Exp Med. 2009; 206(13):2977-2986
Doi: 10.1084/jem.20092176
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Seidel Markus
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Nuclear factor interleukin-3 (Nfil3; also known as E4-binding protein 4) is a basic region leucine zipper transcription factor that has antiapoptotic activity in vitro under conditions of growth factor withdrawal. To study the role of Nfil3 in vivo, we generated gene-targeted Nfil3-deficient (Nfil3(-/-)) mice. Nfil3(-/-) mice were born at normal Mendelian frequency and were grossly normal and fertile. Although numbers of T cells, B cells, and natural killer (NK) T cells were normal in Nfil3(-/-) mice, a specific disruption in NK cell development resulted in severely reduced numbers of mature NK cells in the periphery. This defect was NK cell intrinsic in nature, leading to a failure to reject MHC class I-deficient cells in vivo and reductions in both interferon gamma production and cytolytic activity in vitro. Our results confirm the specific and essential requirement of Nfil3 for the development of cells of the NK lineage.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - physiology
- Cell Lineage -
- Killer Cells, Natural - physiology
- Mice -
- Mice, Inbred C57BL -
- Mice, Knockout -