Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hainz, U; Jürgens, B; Wekerle, T; Seidel, MG; Heitger, A.
Indoleamine 2,3-dioxygenase in hematopoietic stem cell transplantation.
Curr Drug Metab. 2007; 8(3):267-272
Doi: 10.2174/138920007780362554
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Seidel Markus
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- Abstract:
- Hematopoietic stem cell transplantation (HSCT) is complicated by unwelcome side-effects that arise on the basis of an altered immune system. Infectious complications and alloreactive T-cell responses trigger a process of ongoing immune activation and inflammation. Negative-feedback mechanisms to counteract inflammation involve the induction of the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO), which mediates anti-inflammatory activities and T-cell inhibition via tryptophan catabolism. However, persistent immune activation and generalized release of pro-inflammatory cytokines deviate immune regulation towards chronic suppression incapable to abrogate the inflammatory response. This review focuses on the unique role of tryptophan catabolism in modulating inflammatory processes and T-cell responses after HSCT.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Hematopoietic Stem Cell Transplantation -
- Humans -
- Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology
- T-Lymphocytes - immunology
- Find related publications in this database (Keywords)
- indoleamine 2,3-dioxygenase
- HSCT
- T-cell
- transplantation
- tolerance
- inflammation
- CTLA4
- GVHD