Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Seidel, MG; Ernst, U; Printz, D; Juergens, B; Pichler, J; Attarbaschi, A; Fritsch, G; Gadner, H; Heitger, A.
Expression of the putatively regulatory T-cell marker FOXP3 by CD4(+)CD25+ T cells after pediatric hematopoietic stem cell transplantation.
Haematologica. 2006; 91(4): 566-569.
Doi: 10.3324/%25x
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- Abstract:
- FOXP3 has been proposed to be critical for the regulatory function of CD4(+)CD25+ T cells and it has been reported that its expression correlates with protection from graft-versus-host-disease (GvHD) after allogeneic hematopoietic stem cell transplantation (HSCT). Here, by monitoring 28 pediatric HSCT recipients, we found that the levels of FOXP3-mRNA expression in highly enriched CD4(+)CD25+ cells were identical to those in healthy controls irrespective of GvHD status. Moreover, FOXP3-mRNA was abundant in recently in vitro stimulated CD4(+)CD25+ cells that lacked regulatory function. Together these findings suggest that FOXP3-mRNA expression primarily reflects CD4(+)CD25+ cell frequency rather than defining the regulatory potential of CD4(+)CD25+ T cells and GvHD risk after HSCT.
- Find related publications in this database (using NLM MeSH Indexing)
- CD4 Lymphocyte Count -
- Case-Control Studies -
- Child -
- Female -
- Forkhead Transcription Factors - genetics Forkhead Transcription Factors - physiology
- Graft vs Host Disease -
- Hematopoietic Stem Cell Transplantation -
- Humans -
- Male -
- RNA, Messenger - analysis
- T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - metabolism
- Find related publications in this database (Keywords)
- hematopoietic stem cell transplantation
- tolerance
- graft-versus-host disease
- CD4(+)CD25(+) T cells
- FOXP3 expression
- scurfin