Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Seidel, MG; Fritsch, G; Matthes-Martin, S; Lawitschka, A; Lion, T; Pötschger, U; Rosenmayr, A; Fischer, G; Gadner, H; Peters, C.
Antithymocyte globulin pharmacokinetics in pediatric patients after hematopoietic stem cell transplantation.
J Pediatr Hematol Oncol. 2005; 27(10):532-536
Doi: 10.1097/01.mph.0000184575.00717.25
Web of Science
PubMed
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- Seidel Markus
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- Abstract:
- To analyze the dose effects of rabbit-derived antithymocyte globulin (ATG) in children after allogeneic hematopoietic stem cell transplantation (HSCT), ATG serum levels were monitored in 32 children and adolescents (median age 3.42 years, range 0.34-18.67 years) and the incidence of acute and chronic graft-versus-host disease, rejection, viral infections, EBV-lymphoproliferative disease, and survival was correlated with the ATG dose used. Cumulative doses from 7.5 to 20 mg/kg showed a constant half-life and linear correlation between dose and Cmax, whereas higher doses (30-40 mg/kg) accumulated in the body. High-dose ATG is of no benefit for preventing graft-versus-host disease but is associated with a significant increase in EBV-linked disease, and it appears to enhance the susceptibility to fatal viral infections and rejection. These data strongly support the use of a low-dose ATG regimen in pediatric HSCT.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Animals -
- Antilymphocyte Serum - administration and dosage Antilymphocyte Serum - blood
- Child -
- Child, Preschool -
- Cyclosporine - pharmacology
- Dose-Response Relationship, Drug -
- Epstein-Barr Virus Infections - etiology Epstein-Barr Virus Infections - pathology
- Female -
- Graft Rejection - prevention and control
- Graft vs Host Disease - drug therapy
- Hematopoietic Stem Cell Transplantation -
- Herpesvirus 4, Human - isolation and purification
- Histocompatibility Testing -
- Humans -
- Immunosuppressive Agents - administration and dosage Immunosuppressive Agents - blood
- Incidence -
- Infant -
- Lymphoproliferative Disorders - etiology Lymphoproliferative Disorders - pathology
- Male -
- Rabbits -
- Retrospective Studies -
- Transplantation Conditioning -
- Find related publications in this database (Keywords)
- pediatric transplantation immunology
- in vivo T-cell depletion
- graft-versus-host disease prophylaxis
- rejection