Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Meyer, T; Stanske, B; Kochen, MM; Cordes, A; Yüksel, I; Wachter, R; Lüers, C; Scherer, M; Binder, L; Pieske, B; Herrmann-Lingen, C.
Serum levels of interleukin-6 and interleukin-10 in relation to depression scores in patients with cardiovascular risk factors.
Behav Med. 2011; 37(3):105-112
Doi: 10.1080/08964289.2011.609192
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Pieske Burkert Mathias
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- Abstract:
- It is currently unknown whether elevated cytokine levels in depression are confined to any specific subgroup of depressive patients. In this study, medical out-patients presenting with cardiovascular risk factors (N = 356) were assessed for both cognitive-affective and physical symptoms of depression using the Hospital Anxiety and Depression Scale (HADS) and the Maastricht questionnaire (MQ), respectively. In study participants assigned to the highest (≥21) and lowest (≤5) quartile for the MQ score, serum levels of cytokines were measured. We found highly significant associations between cognitive-affective symptoms of depression and elevated serum levels of interleukin-6 (IL-6; ρ = .231; p = .002) and interleukin-10 (IL-10; ρ = .370; p < .001), respectively. In multiple regression models elevated IL-10 serum concentration was independently related to cognitive-affective symptoms of depression (ρ = .165; p = .002). When all cytokines were included in one model, elevated IL-10 serum concentrations remained a significant predictor for depressive mood (ρ = .157; p = .009). In patients with cardiovascular risk factors and extreme scores for vital exhaustion, elevated serum IL-6 and even more IL-10 concentrations are linked to the presence of depressive mood. Future studies will have to test whether the so far unreported association of IL-10 with depressive mood represents a causal pathway involved in the pathogenesis or in the prognostic effect of depressive mood in cardiac patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Biological Markers - blood
- Cardiovascular Diseases - blood
- Cohort Studies -
- Depression - blood
- Female -
- Humans -
- Interleukin-10 - blood
- Interleukin-6 - blood
- Male -
- Middle Aged -
- Psychiatric Status Rating Scales - statistics & numerical data
- Risk Factors -
- Find related publications in this database (Keywords)
- Depression
- vital exhaustion
- cardiovascular patients
- cytokine
- interleukin