Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Harbaum, L; Pollheimer, MJ; Kornprat, P; Lindtner, RA; Schlemmer, A; Rehak, P; Langner, C.
Keratin 7 expression in colorectal cancer--freak of nature or significant finding?
Histopathology. 2011; 59(2):225-234
Doi: 10.1111/j.1365-2559.2011.03694.x
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Langner Cord
- Co-Autor*innen der Med Uni Graz
- Kornprat Peter
- Pollheimer Marion
- Rehak Peter
- Schlemmer Andrea
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- Abstract:
- To assess the prevalence of keratin 7 (K7) expression in colorectal cancer and to correlate findings with clinicopathological parameters and patients' outcome. A total of 370 patients were evaluated for K7 expression by immunohistochemistry using a tissue microarray technique. K7 expression was scored semiquantitatively as either focal (<10%), moderate (10-50%) or extensive (>50%). In all, 32 (9%) tumours were immunoreactive for K7, with five cases showing extensive, four moderate and 23 focal expression, respectively. K7 expression was associated with poor tumour differentiation (P = 0.005) and the extent of tumour budding (P = 0.02). In whole sections, K7 immunoreactivity prevailed in single cells and small clusters of cells at the invasion front. Analysis of serial sections showed that K7-positive cells colocalized with keratin 20, whereas they lacked immunoreactivity for E-cadherin, MUC2 and MIB-1. Disease progression occurred in 52% of patients with K7-positive tumours and 41% with K7-negative tumours (P = 0.19); 48% of patients with K7-positive tumours but only 33% with K7-negative tumours died of disease (P = 0.06). Aberrant expression of K7 in budding cancer cells represents a modification of the epithelial phenotype ('epithelial-epithelial transition': EET) which may be linked to gains in motility and invasive potential. © 2011 Blackwell Publishing Limited.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - diagnosis Adenocarcinoma - metabolism
- Adult -
- Aged -
- Aged, 80 and over -
- Biomarkers, Tumor - metabolism
- Cell Transdifferentiation -
- Colorectal Neoplasms - diagnosis Colorectal Neoplasms - metabolism
- Disease Progression -
- Female -
- Humans -
- Keratin-20 - metabolism
- Keratin-7 - metabolism
- Male -
- Middle Aged -
- Neoplasm Grading -
- Neoplasm Invasiveness -
- Neoplasm Staging -
- Tissue Array Analysis -
- Find related publications in this database (Keywords)
- colorectal cancer
- epithelial mesenchymal transition
- keratin 7
- prognosis
- tumour budding