Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Czabak-Garbacz, R; Schneditz, D; Zierler, E; Eichmann, E; Harter, G; Hafner-Giessauf, H; Obermayer-Pietsch, B.
Blunted insulinemia using high dialysate glucose concentration during hemodialysis.
ASAIO J. 2011; 57(5): 444-450.
Doi: 10.1097/MAT.0b013e318229aaa4
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Czabak-Garbacz Roza
- Schneditz Daniel
- Co-Autor*innen der Med Uni Graz
- Hafner-Giessauf Hildegard Elisabeth
- Obermayer-Pietsch Barbara
- Zierler Edda
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The benefit of high glucose concentrations in the dialysate remains under debate. The aim of this study was to analyze and to compare the acute insulin response using a common but high glucose concentration in the dialysate representing a parenteral mode of glucose administration to oral glucose administration in stable and fasting nondiabetic hemodialysis patients during their routine hemodialysis session. Glucose was either given by a standardized oral load (75 g) or using a glucose concentration of 11.1 mmol/L (200 mg/dL) in the dialysate for the duration of an hour. The insulin response per unit glucose stimulus was determined from the slope of paired insulin and glucose concentrations measured in 15-minute intervals using standard techniques. This slope is mathematically equivalent to the insulinogenic index (IG) and has been shown to be independent of extracorporeal clearance by ongoing hemodialysis. In 10 subjects, the IG was 9.3 ± 2.6 U/mol with oral glucose delivery but only one-third of that value (3.0 ± 1.1 U/mol, p < 0.001) when glucose was delivered through the dialysate. Administration of glucose using dialysate thus leads to a blunted insulin response per unit glucose stimulus. This may cause prolonged hyperglycemia which should be avoided in patients treated with hemodialysis.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Oral -
- Adult -
- Aged -
- Aged, 80 and over -
- Dialysis Solutions - chemistry
- Female -
- Glucose - chemistry Glucose - metabolism Glucose - pharmacology
- Humans -
- Insulin - blood Insulin - chemistry
- Male -
- Middle Aged -
- Models, Theoretical -
- Renal Dialysis - adverse effects Renal Dialysis - methods
- Renal Insufficiency - therapy