Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Olschewski, A.
Targeting TASK-1 Channels as a Therapeutic Approach
ADVAN EXPERIMENT MED BIOL. 2010; 661: 459-473.
Doi: 10.1007/978-1-60761-500-2_30
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Olschewski Andrea
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The voltage-independent background two-pore domain K(+) channel TASK-1 sets the resting membrane potential in excitable cells and renders these cells sensitive to a variety of vasoactive factors. There is clear evidence for TASK-1 in human pulmonary artery smooth muscle cells and TASK-1 channels are likely to regulate the pulmonary vascular tone through their regulation by hypoxia, pH, inhaled anesthetics, and G protein-coupled pathways. Furthermore, TASK-1 is a strong candidate to play a role in hypoxic pulmonary vasoconstriction. On the other hand, consistent with the activation of TASK-1 channels by volatile anesthetics, TASK-1 contributes to the anesthetic-induced pulmonary vasodilation. TASK-1 channels are unique among K(+) channels because they are regulated by both, increases and decreases from physiological pH, thus contributing to their protective effect on the pulmonary arteries. Moreover, TASK-1 may also have a critical role in mediating the vasoactive response of G protein-coupled pathways in resistance arteries which can offer promising therapeutic solutions to target diseases of the pulmonary circulation.
- Find related publications in this database (using NLM MeSH Indexing)
- Anesthetics, Inhalation - metabolism
- Animals -
- Anoxia - metabolism
- Endothelin-1 - metabolism
- Humans -
- Hydrogen-Ion Concentration -
- Muscle, Smooth, Vascular - cytology
- Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - physiology
- Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - classification Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism
- Phylogeny -
- Potassium Channels, Tandem Pore Domain - chemistry Potassium Channels, Tandem Pore Domain - classification Potassium Channels, Tandem Pore Domain - genetics Potassium Channels, Tandem Pore Domain - metabolism
- Protein Isoforms - chemistry Protein Isoforms - classification Protein Isoforms - genetics Protein Isoforms - metabolism
- Pulmonary Artery - cytology
- Receptors, G-Protein-Coupled - metabolism
- Signal Transduction - physiology
- Vasoconstriction - physiology
- Find related publications in this database (Keywords)
- TASK-1
- pulmonary artery
- smooth muscle
- hypoxic pulmonary vasoconstriction
- inhaled anesthetics
- endothelin-1
- prostacyclin