Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Beitzke, M; Enzinger, C; Windpassinger, C; Pfeifer, D; Fazekas, F; Woellner, C; Grimbacher, B; Kroisel, PM.
Community acquired Staphylococcus aureus meningitis and cerebral abscesses in a patient with a Hyper-IgE and a Dubowitz-like syndrome.
J Neurol Sci. 2011; 309(1-2):12-15
Doi: 10.1016/j.jns.2011.07.045
(- Case Report)
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Beitzke Markus
- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
- Fazekas Franz
- Kroisel Peter
- Windpassinger Christian
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- Abstract:
- The Hyper-IgE syndrome (HIES) is a rare primary immunodeficiency which recently has been associated with heterozygous dominant-negative mutations in the signal transducer and activator of transcription 3 (STAT3). Although HIES is characterized by recurrent staphylococcal infections, the microbial invasion of the central nervous system (CNS) is definitively uncommon. We here report on Staphylococcus aureus meningitis and cerebral abscesses acquired in the community in a 31-year-old female patient with a de novo heterozygous mutation of STAT3 and a Dubowitz-like syndrome characterized by growth retardation, microcephaly and eczema. The patient presented with a relative paucity of clinical symptoms despite severe cerebrospinal fluid pathology and multiple cerebral abscesses. Antimicrobial as well as treatment with intravenous immunoglobulin was well tolerated and led to a slow recovery over a 6 months period. Our observation adds community acquired S. aureus meningitis to the list of life-threatening infections in STAT3-deficient HIES and should also raise awareness for the unusual clinical presentation of severe neuroinfection in this syndrome. Whether the association of HIES with Dubowitz-like syndrome was purely coincidental, possibly supportive of the CNS infection, or suggests a genetic overlap of these syndromes, awaits clarification.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Brain Abscess - complications
- Community-Acquired Infections - complications
- Eczema - complications
- Facies -
- Female -
- Growth Disorders - complications
- Humans -
- Intellectual Disability - complications
- Job's Syndrome - complications
- Meningitis, Bacterial - complications
- Microcephaly - complications
- Staphylococcal Infections - complications
- Staphylococcus aureus -
- Find related publications in this database (Keywords)
- Bacterial meningitis
- Community acquired
- Cerebral abscesses
- Immunodeficiency
- Hyper-IgE syndrome