Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Krisper, P; Stadlbauer, V; Stauber, RE.
Clearing of toxic substances: are there differences between the available liver support devices?
Liver Int. 2011; 31 Suppl 3: 5-8.
Doi: 10.1111/j.1478-3231.2011.02588.x
PubMed
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- Führende Autor*innen der Med Uni Graz
- Krisper Peter
- Co-Autor*innen der Med Uni Graz
- Stadlbauer-Köllner Vanessa
- Stauber Rudolf
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- Abstract:
- Toxins accumulating in liver failure split into water solved (e.g. ammonia) and albumin bound substances (e.g. bilirubin). Because the latter cannot be removed by conventional haemodialysis, special liver support systems have been developed. The majority of data concerning elimination efficiency exist for the cell-free devices Molecular Adsorbent Recirculating System (MARS) and Prometheus, as they have been commercially available in Europe since many years. Overall, Prometheus provides higher clearances for most liver toxins, especially if they are tightly albumin bound. However, for bile acids and cytokines no such differences could be found. Single pass albumin dialysis (SPAD) can be assumed to be equally effective as MARS. None of the bioartificial liver support systems being developed is on the market today and published clearance data are scarce. In general, clearance efficiency for albumin bound substances is relatively low in all systems currently available. Besides optimizing biocompatibility and selectivity, future technologies should also focus on improved detoxification efficiency of liver support devices.
- Find related publications in this database (using NLM MeSH Indexing)
- Bilirubin - isolation and purification
- Extracorporeal Circulation - methods
- Humans -
- Liver Failure - therapy
- Liver, Artificial -
- Plasmapheresis - methods
- Renal Dialysis - methods
- Serum Albumin - isolation and purification
- Sorption Detoxification - instrumentation Sorption Detoxification - methods