Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hohloch, K; Delaloye, AB; Windemuth-Kieselbach, C; Gómez-Codina, J; Linkesch, W; Jurczak, W; Cacchione, R; Suh, C; Zinzani, PL; Trümper, L.
Radioimmunotherapy confers long-term survival to lymphoma patients with acceptable toxicity: registry analysis by the international radioimmunotherapy network.
J Nucl Med. 2011; 52(9):1354-1360
Doi: 10.2967/jnumed.111.089920
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- Co-Autor*innen der Med Uni Graz
- Linkesch Werner
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- Abstract:
- The Radioimmunotherapy Network (RIT-N) is a Web-based, international registry collecting long-term observational data about radioimmunotherapy-treated patients with malignant lymphoma outside randomized clinical studies. The RIT-N collects unbiased data on treatment indications, disease stages, patients' conditions, lymphoma subtypes, and hematologic side effects of radioimmunotherapy treatment. Methods: RIT-N is located at the University of Gottingen, Germany, and collected data from 14 countries. Data were entered by investigators into a Web-based central database managed by an independent clinical research organization. Results: Patients (1,075) were enrolled from December 2006 until November 2009, and 467 patients with an observation time of at least 12 mo were included in the following analysis. Diagnoses were as follows: 58% follicular lymphoma and 42% other B-cell lymphomas. The mean overall survival was 28 mo for follicular lymphoma and 26 mo for other lymphoma subtypes. Hematotoxicity was mild for hemoglobin (World Health Organization grade II), with a median nadir of 10 g/dL, but severe (World Health Organization grade III) for platelets and leukocytes, with a median nadir of 7,000/mu L and 2.2/mu L, respectively. Conclusion: Clinical usage of radioimmunotherapy differs from the labeled indications and can be assessed by this registry, enabling analyses of outcome and toxicity data beyond clinical trials. This analysis proves that radioimmunotherapy in follicular lymphoma and other lymphoma subtypes is a safe and efficient treatment option.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Antibodies, Monoclonal - therapeutic use
- Bone Marrow - pathology
- Database Management Systems -
- Databases, Factual -
- Disease Progression -
- Female -
- Hematologic Diseases - etiology
- Humans -
- Internet -
- Lymphoma - pathology
- Lymphoma, Follicular - pathology
- Male -
- Middle Aged -
- Radioimmunotherapy - adverse effects
- Radiopharmaceuticals - therapeutic use
- Registries -
- Stem Cell Transplantation -
- Survival -
- Treatment Outcome -
- Young Adult -
- Find related publications in this database (Keywords)
- B-cell lymphoma
- radioimmunotherapy
- registry
- treatment
- RIT-Network