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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Santacroce, A; Walier, M; Régis, J; Liščák, R; Motti, E; Lindquist, C; Kemeny, A; Kitz, K; Lippitz, B; Martínez Álvarez, R; Pedersen, PH; Yomo, S; Lupidi, F; Dominikus, K; Blackburn, P; Mindermann, T; Bundschuh, O; van Eck, AT; Fimmers, R; Horstmann, GA.
Long-term tumor control of benign intracranial meningiomas after radiosurgery in a series of 4565 patients.
Neurosurgery. 2012; 70(1): 32-39.
Doi: 10.1227/NEU.0b013e31822d408a
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Dominikus Karlheinz
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- Abstract:
- BACKGROUND: Radiosurgery is the main alternative to microsurgical resection for benign meningiomas. OBJECTIVE: To assess the long-term efficacy and safety of radiosurgery for meningiomas with respect to tumor growth and prevention of associated neurological deterioration. Medium-to long-term outcomes have been widely reported, but no large multicenter series with long-term follow-up have been published. METHODS: From 15 participating centers, we performed a retrospective observational analysis of 4565 consecutive patients harboring 5300 benign meningiomas. All were treated with Gamma Knife radiosurgery at least 5 years before assessment for this study. Clinical and imaging data were retrieved from each center and uniformly entered into a database by 1 author (A.S.). RESULTS: Median tumor volume was 4.8 cm(3), and median dose to tumor margin was 14 Gy. All tumors with imaging follow-up, < 24 months were excluded. Detailed results from 3768 meningiomas (71%) were analyzed. Median imaging follow-up was 63 months. The volume of treated tumors decreased in 2187 lesions (58%), remained unchanged in 1300 lesions (34.5%), and increased in 281 lesions (7.5%), giving a control rate of 92.5%. Only 84 (2.2%) enlarging tumors required further treatment. Five-and 10-year progression-free survival rates were 95.2% and 88.6%, respectively. Tumor control was higher for imaging defined tumors vs grade I meningiomas (P < .001), for female vs male patients (P < .001), for sporadic vs multiple meningiomas (P < .001), and for skull base vs convexity tumors (P < .001). Permanent morbidity rate was 6.6% at the last follow-up. CONCLUSION: Radiosurgery is a safe and effective method for treating benign meningiomas even in the medium to long term.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Female -
- Humans -
- Kaplan-Meier Estimate -
- Longitudinal Studies -
- Magnetic Resonance Imaging -
- Male -
- Meningeal Neoplasms - mortality
- Meningioma - mortality
- Microsurgery - methods
- Middle Aged -
- Radiosurgery - methods
- Tomography, X-Ray Computed -
- Tumor Burden -
- Find related publications in this database (Keywords)
- Control rate
- Follow-up
- Meningiomas
- Multicenter study
- Radiosurgery