Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zalaudek, I; Giacomel, J; Schmid, K; Bondino, S; Rosendahl, C; Cavicchini, S; Tourlaki, A; Gasparini, S; Bourne, P; Keir, J; Kittler, H; Eibenschutz, L; Catricalà, C; Argenziano, G.
Dermatoscopy of facial actinic keratosis, intraepidermal carcinoma, and invasive squamous cell carcinoma: A progression model.
J Am Acad Dermatol. 2012; 66(4):589-597
Doi: 10.1016/j.jaad.2011.02.011
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Zalaudek Iris
- Co-Autor*innen der Med Uni Graz
- Schmid-Zalaudek Karin
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- Abstract:
- Background: Little is known about the dermoscopic features of keratinocyte skin cancer. Objective: We sought to determine the dermoscopic features of facial actinic keratosis (AK), intraepidermal carcinoma (IEC), moderately to poorly differentiated invasive squamous cell carcinoma (SCC), and well-differentiated SCC of the keratoacanthoma type. Methods: This was a retrospective analysis of dermoscopic images of histopathologically diagnosed keratinocyte skin cancer. Results: A total of 243 (70 AK, 71 IEC, 78 SCC, and 24 keratoacanthomas) tumors of the face from 243 patients (mean age: 71.1 years; range: 44-94 years) were analyzed. The majority of patients had a fair skin type, history of melanoma or nonmelanoma skin cancer, and multiple AK. A red pseudonetwork was significantly associated with AK (P < .001), whereas dotted/glomerular vessels, diffuse yellow opaque scales, and microerosions were significantly more prevalent among IEC (P < .001). Hairpin vessels, linear-irregular vessels, targetoid hair follicles, white structureless areas, a central mass of keratin, and ulceration were significantly associated with invasive SCC (P < .001 for all criteria). Similar patterns as in SCC were observed among keratoacanthomas. Limitations: The retrospective design of our study and the lack of assessment of sensitivity and specificity of the dermoscopic criteria are limitations. Conclusions: Based on our findings we propose a progression model of facial AK developing into IEC and invasive SCC. (J Am Acad Dermatol 2012;66:589-97.)
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Carcinoma, Squamous Cell - pathology
- Dermoscopy -
- Disease Progression -
- Facial Dermatoses - pathology
- Female -
- Humans -
- Keratoacanthoma - pathology
- Keratosis, Actinic - pathology
- Male -
- Middle Aged -
- Models, Biological -
- Neoplasm Invasiveness -
- Retrospective Studies -
- Skin Neoplasms - pathology
- Find related publications in this database (Keywords)
- actinic keratosis
- dermatoscopy
- nonmelanoma skin cancer
- squamous cell carcinoma