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SHR Neuro Cancer Cardio Lipid Metab Microb
Bodlaj, G; Pichler, R; Brandstätter, W; Hatzl-Griesenhofer, M; Maschek, W; Biesenbach, G; Berg, J.
Hyperthyroidism affects arterial stiffness, plasma NT-pro-B-type natriuretic peptide levels, and subendocardial perfusion in patients with Graves' disease.
Ann Med. 2007; 39(8):608-616
Doi: 10.1080/07853890701528579
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Berg Jörg
- Pichler Robert
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- Abstract:
- BACKGROUND: Arterial stiffness is thought to play a critical role in the pathogenesis of cardiovascular events, and in hyperthyroidism increased cardiovascular event rates have been reported. AIM: To investigate markers of systemic arterial stiffness, volume homeostasis, and subendocardial perfusion and its interrelationship in patients with Graves' disease (GD) in hyperthyroidism and euthyroidism. METHOD: Aortic augmentation index (AIx@75) as a measure of systemic arterial stiffness and subendocardial viability ratio (SEVR) as a surrogate measure of subendocardial perfusion were assessed by applanation tonometry in 59 patients with GD in hyperthyroidism and euthyroidism, and measurements were compared to plasma levels of NT-pro-B-type natriuretic peptide (NT-ProBNP). RESULTS: AIx@75 and NT-ProBNP levels were significantly increased in hyperthyroidism compared to euthyroidism and were positively correlated with each other. SEVR was significantly decreased in hyperthyroidism compared to euthyroidism, mainly due to increased heart rates as shown by the heart rate-corrected SEVR75. CONCLUSIONS: In hyperthyroidism, patients with GD exhibited increased systemic arterial stiffness, paralleled by increased levels of NT-ProBNP, a marker of volume overload. The decreased subendocardial perfusion in hyperthyroidism seemed to be mainly due to increased heart rates. The observed unfavorable hemodynamic alterations in hyperthyroidism may serve to explain increased cardiovascular event rates in patients with GD.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Arteries - pathology
- Elasticity -
- Female -
- Graves Disease - blood
- Humans -
- Hyperthyroidism - blood Hyperthyroidism - pathology Hyperthyroidism - physiopathology
- Male -
- Middle Aged -
- Natriuretic Peptide, Brain - blood
- Peptide Fragments - blood
- Thyroxine - blood
- Triiodothyronine - blood
- Find related publications in this database (Keywords)
- Graves' disease
- hyperthyroidism
- NT-ProBNP
- subendocardial perfusion
- systemic arterial stiffness