Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Steinwender, C; Hofmann, R; Kammler, J; Kypta, A; Pichler, R; Maschek, W; Schuster, G; Gabriel, C; Leisch, F.
Effects of peripheral blood stem cell mobilization with granulocyte-colony stimulating factor and their transcoronary transplantation after primary stent implantation for acute myocardial infarction.
Am Heart J. 2006; 151(6):1296.e7-1296.13
Doi: 10.1016/j.ahj.2006.03.012
PubMed
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- Co-Autor*innen der Med Uni Graz
- GABRIEL Christian
- Pichler Robert
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- Abstract:
- There is increasing evidence that transplantation of autologous stem cells improves cardiac function after acute myocardial infarction (AMI). For propagation of peripheral blood stem cells (PBSCs), application of granulocyte-colony stimulating factor (G-CSF) has been shown to be feasible, effective, and safe. We sought to evaluate a clinical and angiographic long-term safety profile of G-CSF application combined with transcoronary PBSC transplantation after recent stent implantation for AMI. In patients with AMI and successful primary stenting of the infarct-related coronary artery, pharmacological bone marrow stimulation with G-CSF was initiated on the second postinterventional day. At least after 4 days of G-CSF therapy, apheresis as well as transcoronary transplantation of PBSCs was performed. The PBSCs were infused via a balloon catheter which was inflated inside the stent. Ventriculography and quantitative coronary angiography were performed at baseline and after 6 months. In the 20 patients who received PBSCs, mean left ventricular ejection fraction improved from 46.4% +/- 8.1% at baseline to 54.3% +/- 11% after 6 months (P < .001) because of an increase in systolic function in the infarct region. Control coronary angiography revealed a significant in-stent restenosis of the infarct-related coronary artery, defined as >50% stenosis, in 8 patients (40%), which was complicated by reinfarction in 2 patients (10%). Transcoronary transplantation of G-CSF-mobilized PBSCs favorably influences cardiac function and can be performed without adverse periprocedural events. However, significant in-stent restenosis and reinfarction seem to occur frequently during the following 6 months.
- Find related publications in this database (using NLM MeSH Indexing)
- Combined Modality Therapy -
- Female -
- Granulocyte Colony-Stimulating Factor - therapeutic use
- Hematopoietic Stem Cell Mobilization -
- Humans -
- Male -
- Middle Aged -
- Myocardial Infarction - therapy
- Prospective Studies -
- Stents -