Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bodlaj, G; Berg, J; Pichler, R; Sailer, T; Biesenbach, G.
Type 2 diabetes in patients with end-stage renal disease is not associated with further increased serum inflammatory parameters.
J Nephrol. 2004; 17(1):112-117
Web of Science
PubMed
- Co-Autor*innen der Med Uni Graz
- Berg Jörg
- Pichler Robert
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- Abstract:
- BACKGROUND: Cardiovascular morbidity and mortality is markedly increased in patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD) and is further pronounced when diabetes mellitus is also present. As atherogenesis is mediated by inflammation of vessel walls and as evidence evolves that atherosclerosis and diabetes mellitus share a common inflammatory basis, we considered whether ESRD patients with additional diabetes mellitus exhibit increased inflammation levels exceeding those of ESRD patients without diabetes mellitus. METHODS: The study included 20 ESRD patients with type 2 diabetes mellitus and 16 non-diabetic ESRD patients on long-term HD. The patients' clinical characteristics and serum levels of C-reactive protein (CRP), interleukin 6 (IL-6), soluble tumor necrosis factor receptor I (sTNF-RI), neopterin and fibrinogen were assessed. RESULTS: There were no significant differences in serum levels of CRP, IL-6, neopterin, sTNF-RI and fibrinogen found in ESRD patients with and without diabetes mellitus. HD duration correlated significantly with neopterin (r=0.515, p<0.001) and sTNF-RI (r=0.429, p<0.05) serum levels. HD led to a significant reduction in neopterin levels whereas CRP, IL-6 and sTNF-RI levels did not change significantly. CONCLUSIONS: With the inherent limitations of a small number of patients studied, we observed that the presence of type 2 diabetes mellitus in addition to ESRD was not associated with further increased serum levels of the examined inflammatory parameters. Our observations suggest that the worsened prognosis of diabetic ESRD patients is probably not explainable by superimposing inflammatory processes.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Antigens, CD - blood
- Arteriosclerosis - blood Arteriosclerosis - diagnosis Arteriosclerosis - etiology
- C-Reactive Protein - analysis
- Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications
- Diabetic Nephropathies - blood Diabetic Nephropathies - therapy
- Female -
- Fibrinogen - analysis
- Humans -
- Inflammation Mediators - blood
- Interleukin-6 - blood
- Kidney Failure, Chronic - blood Kidney Failure, Chronic - therapy
- Male -
- Middle Aged -
- Neopterin - blood
- Receptors, Tumor Necrosis Factor - blood
- Receptors, Tumor Necrosis Factor, Type I -
- Renal Dialysis -
- Find related publications in this database (Keywords)
- atherosclerosis
- diabetes
- end-stage renal disease
- hemodialysis
- inflammation