Medizinische Universität Graz - Research portal
Selected Publication:
Pichler, R; Maschek, W; Hatzl-Griesenhofer, M; Huber, H; Crespillo-Gómez, C; Berg, J.
Soluble tumour necrosis factor-alpha receptor I and interleukin-6 as markers of activity in thyrotoxic Graves' disease.
Horm Metab Res. 2003; 35(7): 427-433.
Doi: 10.1055/s-2003-41624
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Pichler Robert
- Co-authors Med Uni Graz
- Berg Jörg
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- Abstract:
- Autoimmune thyroid diseases are thought to be mediated by pro-inflammatory cytokines such as TNFalpha and IL-6. Serum levels of cytokines may indicate activity levels of immune functions. We investigated serum levels of IL-6 and of the soluble receptor of TNFalpha in patients with newly diagnosed onset of Graves' hyperthyroidism. The predominantly female group consisted of 39 patients, mean fT4 was 47.6 pg/ml (normal values 7.5=19.0 pg/ml). After diagnosis, all patients were treated with anti-thyroid drugs. Soluble Tumour Necrosis Factor Receptor I (TNF-RI) serum levels were found significantly increased (mean 3.7+/-1.3 ng/ml; p<0,01) compared to a matched group of apparent healthy individuals (mean sTNF-RI 1.8+/-0.5 ng/ml) and to a matched group of patients with treated Graves' disease (mean sTNF-RI 1.9+/-0.6 ng/ml). When IL-6 was assessed only 4 of the 39 patients exhibited increased serum levels. Our finding may indicate that sTNF-RI and possibly its ligand, TNFalpha, could play an important role in the onset of the acute stage of Graves' disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- C-Reactive Protein - metabolism
- Female -
- Graves Disease - immunology
- Humans -
- Immunoenzyme Techniques -
- Interleukin-6 - blood Interleukin-6 - immunology
- Male -
- Receptors, Tumor Necrosis Factor - blood Receptors, Tumor Necrosis Factor - immunology
- Regression Analysis -
- Thyrotropin - blood
- Triiodothyronine - blood
- Find related publications in this database (Keywords)
- TNF receptor
- cytokines
- hyperthyreosis
- Graves' disease