Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Pichler, R; Maschek, W; Krieglsteiner, S; Raml, A; Schmekal, B; Berg, J.
Pro-inflammatory role of serotonin and interleukin-6 in arthritis and spondyloarthropathies--measurement of disease activity by bone scan and effect of steroids.
Scand J Rheumatol. 2002; 31(1):41-43
Doi: 10.1080/030097402317255363
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Pichler Robert
- Co-Autor*innen der Med Uni Graz
- Berg Jörg
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- Abstract:
- OBJECTIVE: As serotonin is a mediator of inflammatory joint disease, serum levels were investigated in human patients with arthritis for a possible corresponding role as a disease marker. DESIGN: 48 patients were evaluated by bone scan for disease activity. 5-HT and CRP were measured in the whole group, and IL-6 in those not yet receiving corticosteroids. The pro-inflammatory parameters were compared to each other and to scintigraphic features. RESULTS: The serum levels of serotonin did not correspond to disease activity measured by CRP, IL-6 or activity on joints in skeletal scintigraphy. No difference was seen in comparison to the values of a control group, but when glucocorticoid treatment was included, low 5-HT serum values were observed. A significant correlation between CRP and IL-6 as indicators of inflammation and bone scan results versus CRP could be shown. CONCLUSION: The measurement of serum serotonin provides no relevant information about disease activity in synovial inflammation. For monitoring osteoarthritis and synovial inflammation, bone scan and laboratory determination of CRP and IL-6 together appear to present useful information about infestation in the disease process.
- Find related publications in this database (using NLM MeSH Indexing)
- Anti-Inflammatory Agents - therapeutic use
- Arthritis - blood Arthritis - drug therapy Arthritis - radionuclide imaging
- Bone and Bones - radionuclide imaging
- C-Reactive Protein - analysis
- Female -
- Humans -
- Interleukin-6 - blood
- Male -
- Middle Aged -
- Prednisolone - therapeutic use
- Radionuclide Imaging - methods
- Serotonin - blood
- Find related publications in this database (Keywords)
- serotonin
- arthritis
- inflammation
- cytokine
- bone scintigraphy