Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Pichler, R; Maschek, W; Holzinger, C.
Therapy with somatostatin analogs in patient with orbitopathy and positive Octreoscan.
Acta Med Austriaca. 2001; 28(4):99-101
Doi: 10.1046/j.1563-2571.2001.01024.x
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- Führende Autor*innen der Med Uni Graz
- Pichler Robert
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- Abstract:
- We prospectively evaluated 28 persons with active endocrine ophthalmopathy and positive sonographic criteria (A-mode) on extraocular eye muscles. To evaluate somatostatin-receptor status SPECT of the orbits was performed with a double-headed rotating gamma camera after application of 110 MBq 111-In-Pentreotide. 9 patients (12/56 eyes respectively) showed a marked uptake ratio (> 2 in circular ROIs by semiquantitative calculation) and were selected for lanreotide (30 mg i.m. every 14 d) treatment. 5 individuals had control scan after clinical progression which became positive in two of them. All but one tolerated modest side-effects of lanreotide treatment (diarrhea). Therapy was discontinued after 3-10 months when thyroid eye disease had lead to fibrotic stage. This subgroup, with the exception of two women, who received corticosteroids additionally, presented stable disease. One of those had to be sent to surgery because of endangered optical nerve. Clinical ophthalmological control showed promising results in patients receiving somatostatin analogues at early stage when positive on octreo-scan.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Female -
- Gamma Cameras -
- Graves Disease - drug therapy Graves Disease - radionuclide imaging
- Hormones - diagnostic use Hormones - therapeutic use
- Humans -
- Male -
- Octreotide - adverse effects Octreotide - analogs and derivatives Octreotide - diagnostic use Octreotide - therapeutic use
- Tomography, Emission-Computed, Single-Photon -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Graves' disease
- endocrine orbitopathy
- somatostatin analogues
- octreoscan