Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Pichler, R; Maschek, W; Hatzl-Griesenhofer, M; Huber, H; Wimmer, G; Wahl, G; Fridrik, M.
Clinical value of FDG PET using coincident gamma cameras in staging and restaging of malignant lymphoma--compared with convenitonal diagnostic methods.
Nuklearmedizin. 2000; 39(6):166-173
Doi: 10.1055/s-0038-1632265
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Pichler Robert
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- Abstract:
- Aim of the present retrospective study was to validate the clinical value of F-18-FDG PET imaging in lymphoma patients with a dual head camera modified for coincidence detection. Staging before and after oncological treatment was compared with a conservative diagnostic approach. Methods: 48 patients (28 non-Hodgkin lymphoma, 20 Hodgkin's disease) received FOG-Hybrid-PET scans. Pretherapeutic staging was realized in 28 patients, 9 of them had control studies after they had completed therapy Totally 29 persons were examined for posttherapeutic restaging. Computed tomography imaging and lymph node sonography was performed in all cases. Results were validated by clinical follow-up, in three cases a recidive was proven by biopsy. Results: CT and ultrasound detected 77 lesions in 28 patients compared with 100 visualized by PET, but this difference in pretherapeutic staging did not reach significance at p > 0.05 by Fisher's t-test. Hybrid-PET obtained a sensitivity of 93%, a specifity of 79%, a positive of 82% and a negative predictive value of 92% for detection of residual disease. The values for CT + US were 87%, 64%, 72% and 88% respectively Conclusion: FDG Hybrid-PET is as or even more accurate than standard morphologic diagnostic methods for prestaging in malignant lymphoma. Additionally, there is a substancial benefit for therapy monitoring of residual disease using coincidence detection PET with a 3/4-inch crystal gamma camera.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Female -
- Fluorodeoxyglucose F18 - diagnostic use
- Hodgkin Disease - pathology Hodgkin Disease - radiography Hodgkin Disease - radionuclide imaging Hodgkin Disease - ultrasonography
- Humans -
- Lymphoma - pathology Lymphoma - radionuclide imaging
- Lymphoma, Non-Hodgkin - pathology Lymphoma, Non-Hodgkin - radiography Lymphoma, Non-Hodgkin - radionuclide imaging Lymphoma, Non-Hodgkin - ultrasonography
- Male -
- Middle Aged -
- Neoplasm Staging - methods
- Neoplasm, Residual - pathology Neoplasm, Residual - radionuclide imaging
- Predictive Value of Tests -
- Radiopharmaceuticals - diagnostic use
- Recurrence -
- Reproducibility of Results -
- Retrospective Studies -
- Tomography, Emission-Computed -
- Tomography, X-Ray Computed -
- Find related publications in this database (Keywords)
- FDG
- coincidence gamma camera
- lymphoma