Medizinische Universität Graz - Research portal
Selected Publication:
Holzer, P; Lippe, IT.
Gastric mucosal hyperemia due to acid backdiffusion depends on splanchnic nerve activity.
Am J Physiol. 1992; 262(3 Pt 1):G505-G509
Doi: 10.1152/ajpgi.1992.262.3.G505
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- Leading authors Med Uni Graz
- Holzer Peter
- Co-authors Med Uni Graz
- Lippe Irmgard Theresia
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- Abstract:
- Acid backdiffusion through a disrupted gastric mucosal barrier leads to an increase in gastric mucosal blood flow (MBF). This response involves afferent neurons that pass through the celiac ganglion. The present study examined the neural pathways that underlie the rise in MBF caused by gastric perfusion with 15% ethanol in 0.15 N HCl. MBF was measured by the hydrogen gas clearance technique in urethan-anesthetized rats. Mucosal hyperemia due to acid backdiffusion was not changed by acute bilateral subdiaphragmatic vagotomy but was blocked by acute removal of the celiac-superior mesenteric ganglion complex or acute bilateral transection of the greater splanchnic nerves. Hexamethonium (85 mumol/kg iv) also attenuated the rise in MBF due to acid backdiffusion, whereas guanethidine (0.225 mmol/kg sc) had no effect. None of the procedures and drug treatments altered basal MBF to a significant extent. Transection of the splanchnic nerves, hexamethonium, and guanethidine lowered mean arterial blood pressure, but hypotension as such did not significantly influence the hyperemic response under study. Taken together, the previous and present data indicate that the rise in MBF caused by acid backdiffusion depends on the integrity of afferent and efferent neural pathways that run in the splanchnic nerves and through the celiac ganglion. The efferent pathway involves ganglionic transmission through nicotinic acetylcholine receptors but is independent of noradrenergic neurons.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blood Pressure - drug effects
- Diffusion -
- Ethanol - pharmacology
- Female -
- Gastric Mucosa - blood supply Gastric Mucosa - innervation
- Guanethidine - pharmacology
- Hexamethonium -
- Hexamethonium Compounds - pharmacology
- Hydrochloric Acid - pharmacology
- Hyperemia - etiology
- Male -
- Neural Pathways -
- Rats -
- Rats, Inbred Strains -
- Regional Blood Flow - drug effects
- Splanchnic Nerves - physiology
- Sympathetic Nervous System - physiology
- Vagotomy -
- Find related publications in this database (Keywords)
- Gastric Mucosal Blood Flow
- Hydrogen Gas Clearance
- Disruption of Gastric Mucosal Barrier
- Vagus Nerve
- Splanchnic Nerve
- Celiac Ganglion
- Sympathetic Nervous System
- Guanethidine
- Hexamethonium